Effects of atypical antipsychotics on blood thyroid hormones and lipids in children and adolescents with schizophrenia
DUAN Xiaxia1 ZHANG Yan2 ZHANG Meng1 YU Yanju1
1.Clinical Laboratory, Xi′an Mental Health Center, Shaanxi Province, Xi′an 710100, China;
2.Pharmacy Laboratory, Xi′an Mental Health Center, Shaanxi Province, Xi′an 710100, China
Abstract：Objective To investigate the effects of atypical antipsychotics on blood thyroid hormones and lipids in children and adolescents with schizophrenia. Methods From September 2015 to July 2017, the clinical data of inpatients in the Department of Child and Adolescent Psychology in Xi′an Mental Health Center was analyzed retrospectively. A total of 86 patients with application of single drug were selected and divided into the Aripiprazole group (29 cases), the Olanzapine group (29 cases) and the Risperidone group (28 cases) according to different drugs they took. Each group was given drugs from small doses for 6 weeks. Before and after treatment, the levels of thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) were analyzed, and the efficacy and safety of each drug were evaluated by positive and negative symptoms scale (PANSS) and treatment emergent symptom scale (TESS). Results ①After treatment, the scores of PANSS in the three groups were significantly lower than those before treatment (P ＜ 0.01). ②In Olanzapine group, the levels of TC, TG, LDL and HDL were significantly higher than those before treatment (P ＜ 0.01 or P ＜ 0.05), while T4 and FT4 were significantly lower than those before treatment (P ＜ 0.01); in Risperidone group, LDL was significantly higher than that before treatment (P ＜ 0.01), and T3 and T4 were significantly lower than those before treatment (P ＜ 0.05); Aripiprazole had no significant differences on blood lipids and thyroid hormones (P ＞ 0.05). ③Comparison among the three groups showed that Olanzapine had the greatest effect on lipids, and Risperidone had the greatest effect on T3. ④There was no significant difference of the incidence of adverse reactions among the three groups (P > 0.05). Conclusion Aripiprazole, Olanzapine and Risperidone have significant therapeutic effects on children and adolescents with schizophrenia. Aripiprazole has no significant effect on blood lipids and thyroid hormones, Olanzapine affects blood lipids significantly, Risperidone affects T3 significantly.
2019, Vol. 16 
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