Effect of dynamic blood glucose monitoring combined with insulin pump in the treatment of gestational diabetes mellitus on secretory frizzled related protein 5 and neonatal prognosis
CHEN Fengling SUN Donghua YANG Hongying GUO Dongqing
Department of Obstetrics, the No.4 People′ Hospital of Hengshui，Hebei Province, Hengshui 053000, China
Abstract：Objective To investigate the dynamic blood glucose monitoring combined with insulin pump in the treatment of gestational diabetes mellitus on secreted frizzled related protein 5 (Sfrp5) and neonatal prognosis. Methods The clinical data of 84 patients with gestational diabetes mellitus who were diagnosed with oral glucose tolerance test (OGTT) in the Department of Obstetrics, the No 4 People′ Hospital of Hengshui from May 2015 to May 2017 were retrospectively analyzed. They were divided into study group (n = 42) and control group (n = 42) according to the treatment method. The study group was treated with dynamic blood glucose monitoring combined with insulin pump, and the control group was treated with dynamic blood glucose monitoring combined with insulin injection. Blood glucose, insulin, Sfrp5 levels, islet resistance index (HOMA-IR) and neonatal prognosis were compared between the two groups. Results After treatment, the levels of fasting blood glucose and postprandial 2 h blood glucose, fasting insulin and HOMA-IR were lower than before treatment (all P < 0.05), and the study group was lower than the control group (all P < 0.05); the Sfrp5 levels in the latter two groups were higher than those before treatment (P < 0.05), and the study group was higher than the control group (P < 0.05). The incidence of adverse neonatal outcomes in the study group was significantly lower than that in the control group(P < 0.05). Conclusion Dynamic blood glucose monitoring combined with insulin pump in the treatment of gestational diabetes mellitus, can significantly improve the Sfrp5 level of pregnant women, and improve blood sugar and insulin levels of patients, reduce the incidence of neonatal adverse pregnancy outcomes, it is worthy of clinical promotion and application.
陈凤玲 孙东华 杨洪英 郭冬青. 动态血糖监测联合胰岛素泵治疗妊娠期糖尿病对分泌型卷曲相关蛋白5及新生儿预后的影响[J]. 中国医药导报, 2019, 16(5): 138-141.
CHEN Fengling SUN Donghua YANG Hongying GUO Dongqing. Effect of dynamic blood glucose monitoring combined with insulin pump in the treatment of gestational diabetes mellitus on secretory frizzled related protein 5 and neonatal prognosis. 中国医药导报, 2019, 16(5): 138-141.
[1] 贺星星，马晓静，周健.动态血糖监测在妊娠合并糖尿病患者中的临床应用[J].中国糖尿病杂志，2015，7（10）：649-651.
[2] Hirst JE，Loerup L，Mackillop L，et al. Digital blood glucose monitoring could provide new objective assessments of blood glucose control in women with gestational diabetes [J]. Diabet Med，2016，33（11）：1598-1599.
[3] 邓惠宜，周丽华，谢志岳，等.24 h动态血糖监测系统在妊娠期糖尿病患者胰岛素治疗中的应用[J].海南医学，2016，27（16）：2689-2690.
[4] 刘晓宏，杜海涛，刘晓宁，等.动态血糖监测联合胰岛素泵对妊娠期糖尿病患者疗效及妊娠结局的影响[J].解放军预防医学杂志，2017，35（S2）：93-95.
[5] Soffer MD，Factor SH，Rosenman A，et al. Improving Postpartum Glucose Monitoring in Women with Gestational Diabetes [J]. J Matern Fetal Neonatal Med，2017，30（24）：3014-3019.
[6] Kizirian NV，Goletzke J，Brodie S，et al. Lower glycemic load meals reduce diurnal glycemic oscillations in women with risk factors for gestational diabetes [J]. Bmj Open Diabetes Res Care，2017，5（1）：e000 351.
[7] Ouchi NA，Higuchi K，Ohashi，et al. Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity [J].Science，2010，329（5990）：454-457.
[8] 贾晓炜，栾进.胰岛素两种给药方式对妊娠糖尿病疗效的比较[J].武警医学，2017，28（5）：483-486.
[9] Carreiro MP，Lauria MW，Naves GN，et al. Seventy two-hour glucose monitoring profiles in mild gestational diabetes mellitus：differences from healthy pregnancies and influence of diet counseling [J].Eur J Endocrinol，2016， 175（3）：201-209.
[10] 杨蕾，李艳，杨玲竹.胰岛素泵双波疗法对妊娠期糖尿病患者妊娠结局的影响[J].中国计划生育学杂志，2017， 25（7）：455-458.
[11] Mendezfigueroa H，Schuster M，Maggio L，et al. Gestational Diabetes Mellitus and Frequency of Blood Glucose Monitoring：A Randomized Controlled Trial [J].Ultrasound Obstet Gynecol，2017，130（1）：163-170.
[12] 沈赟，孙睿，丁波.动态血糖在妊娠期糖尿病患者胰岛素强化治疗期间的临床应用价值[J].重庆医学，2015（36）：5152-5154.
[13] Bernstein JA，Lois MC，Gebel CM，et al. Lost opportunities to prevent early onset type 2 diabetes mellitus after a pregnancy complicated by gestational diabetes [J]. BMJ Open Diabetes Res Care，2016，4（1）：e000 250.
[14] Mendezfigueroa H，Schuster M，Maggio L，et al. Gestational Diabetes Mellitus and Frequency of Blood Glucose Monitoring：A Randomized Controlled Trial [J]. Curr Opin Obstet Gynecol，2017，130（1）：163-170.
[15] 宁改君，任卫东，董运成，等.胰岛素泵强化降糖治疗对合并冠心病的2型糖尿病患者血糖波动及胰岛素抵抗指数的影响[J].宁夏医科大学学报，2017，39（8）：659-660.
[16] Cosson E，Baz B，Gary F，et al. Poor Reliability and Poor Adherence to Self-Monitoring of Blood Glucose are Common in Women with Gestational Diabetes Mellitus and May Be Associated with Poor Pregnancy Outcomes [J]. Diabetes Care，2017，40（9）：1181-1186.
[17] 韩一栩.两种血糖监测方法在妊娠期糖尿病和2型糖尿病合并妊娠患者中的应用效果观察[J].海南医学，2015（14）：2122-2124.
[18] Schinner S. Wnt-signalling and the metabolic syndrome [J]. Horm Metab Res，2009，41（2）：159-163.
[19] Miranda TS，Napimoga MH，Feres M，et al. Antagonists of Wnt/β-catenin signaling in the periodontitis associated with type 2 diabetes and smoking [J]. J Clin Periodontol，2017，45（3）：293-302.
[20] Kintiraki E，Goulis DG，Mameletzi S，et al. Large-and Small-for-Gestational-Age neonates born by women with gestational diabetes mellitus diagnosed by the new IADPSG criteria：a case control study of 289 patients and 1 108 controls [J]. Exp Clin Endocrinol Diabetes，2013， 121（5）：262-265.
[21] Barnes RA，Edghill N，Mackenzie J，et al. Predictors of large and small for gestational age birthweight in offspring of women with gestational diabetes mellitus [J]. Diabet Med，2013，30（9）：1040-1046.
2019, Vol. 16 
京公网安备 11010502046598号