Expression and significance of D-bifunctional protein in endometrial carcinoma
LU Xin1 KONG Lingyu2▲
1.Department of Laboratory, Tangshan Maternal and Child Health Care Hospital, Hebei Province, Tangshan 063000, China;
2.College of Chinese and Western Medicine, Hebei Medical University, Hebei Province, Shijiazhuang 050017, China
Abstract：Objective To detect the expression level of D-bifunctional protein (DBP) in endometrial cancer tissues and its correlation with the detection results of serum tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125), and to explore the clinical significance of DBP in the diagnosis and treatment of endometrial cancer. Methods From January 2013 to December 2015, 30 cases of patients undergoing endometrial cancer resection in Tangshan Maternal and Child Health Care Hospital (hereinafter referred to as "our hospital") were selected as the experimental group, and 20 cases of normal persons who underwent physical examination during the same period in our hospital were selected as the control group. Chemiluminescence was used to detect the expression levels of serum tumor markers CEA and CA125, and immunohistochemistry was used to detect the expression levels of DBP in endometrial and paracancer tissues, and the integral optical density value (IOD) was measured. Pearson correlation analysis was used to analyze the correlation between DBP and tumor markers CEA and CA125. Results The expression of IOD value of DBP in endometrial carcinoma was higher than that in adjacent tissues, and the difference was statistically significant (P ＜ 0.05). There was a positive linear correlation between DBP and tumor markers CEA (r = 0.837, P < 0.01) and CA125 (r = 0.787, P < 0.01). Conclusion The expression of DBP is increased in patients with endometrial cancer and is closely related to the occurrence and development of endometrial cancer. The combined detection of CEA, CA125 and DBP has important significance for the early diagnosis of endometrial cancer, and provides a new research target for the treatment and prognosis of endometrial cancer.
路欣1 孔令玉2▲. D-双功能蛋白在子宫内膜癌组织中的表达及意义[J]. 中国医药导报, 2019, 16(4): 161-163,168.
LU Xin1 KONG Lingyu2▲. Expression and significance of D-bifunctional protein in endometrial carcinoma. 中国医药导报, 2019, 16(4): 161-163,168.
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2019, Vol. 16 
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