Advances in anti-inflammatory mechanism of berberine
LI Hongmei1 DANG Wantai2,3 YANG Xiaohong1
1.Department of Microbiology and Immunology, North Sichuan Medical College, Sichuan Province, Nanchong 637000, China;
2.Institute of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Sichuan Province, Nanchong 637000, China; 3.Department of Rheumatology, Second Clinical Medical College, North Sichuan Medical College, Sichuan Province, Nanchong 637000, China
Abstract:Berberine is an isoquinoline alkaloid. It was used as a broad-spectrum antimicrobial agent in the clinical treatment of pseudomembranous enteritis, chronic gastritis, peptic ulcer and pneumonia. In recent years, with the pharmacological effects of berberine research, its anti-inflammatory mechanism has gradually become a hot research. In this paper, the clinical anti-inflammatory mechanism and research status of berberine in recent years were briefly reviewed, which provided the theoretical basis for the anti-inflammatory mechanism of berberine.
[1] 肖培根,肖伟,许利嘉,等.黄连及含小檗碱类生物碱的中草药[J].中国现代中药,2016(11):1381-1385.
[2] Zou K,Li Z,Zhang Y,et al. Advances in the study of berberine and its derivatives:a focus on anti-inflammatory and anti-tumor effects in the digestive system [J]. Acta Pharmacol Sin,2017,38(2):157-167.
[3] Cicero AF,Baggioni A. Berberine and its role in chronic disease [J]. Adv Exp Med Biol,2016,928:27-45.
[4] Halvorsen B,Santilli F,Scholz H,et al. LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro [J]. Diabetologia,2016,59(10):2134-2144.
[5] Dain A,Repossi G,Diaz-Gerevini GT,et al. Long chain polyunsaturated fatty acids(LCPUFAs)and nordihydroguaiaretic acid(NDGA)modulate metabolic and inflammatory markers in a spontaneous type 2 diabetes mellitus model (Stillman Salgado rats)[J]. Lipids Health Dis,2016,15(1):205.
[6] Singh K,Agrawal NK,Gupta SK,et al. Increased expression of TLR9 associated with pro-inflammatory S100A8 and IL-8 in diabetic wounds could lead to unresolved inflammation in type 2 diabetes mellitus (T2DM) cases with impaired wound healing [J]. J Diabetes Complications,2016, 30(1):99-108.
[7] Xie X,Chang X,Chen L,et al. Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling [J]. Mol Cell Endocrinol,2013,381(1-2):56-65.
[8] Zhao Y,Tang Z,Zhu X,et al. TAB3 involves in hepatic insulin resistance through activation of MAPK pathway [J]. Gen Comp Endocrinol,2015,224:228-234.
[9] 贾燕珺,李建军.小檗碱的抗动脉粥样硬化作用及其机制[J].中国动脉硬化杂志,2013,21(4):364-368.
[10] Feng M,Zou Z,Zhou X,et al. Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE-/- mice [J]. Int Immunopharmacol,2017,43:195-202.
[11] Li H,He C,Wang J,et al. Berberine activates peroxisome proliferator-activated receptor gamma to increase athero?鄄sclerotic plaque stability in Apoe-/- mice with hyperhomocysteinemia [J]. J Diabetes Investig,2016,7(6):824-832.
[12] Blaschke F,Bruemmer D,Law RE. Egr-1 is a major vascular pathogenic transcription factor in atherosclerosis and restenosis [J]. Rev Endocr Metab Disord,2004,5(3):249-254.
[13] Liang KW,Ting CT,Yin SC,et al. Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury [J]. Biochem Pharmacol,2006,71(6):806-817.
[14] 张仁霞,傅永锦,梁基智,等.小檗碱治疗大鼠免疫复合性溃疡性结肠炎及下调炎性细胞因子作用[J].临床医学工程,2014(11):1406-1409.
[15] Li YH,Xiao HT,Hu DD,et al. Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses [J]. Pharmacol Res,2016,110:227-239.
[16] Li C,Xi Y,Li S,et al. Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation [J]. Mol Immunol,2015,67(2 Pt B):444-454.
[17] Choe JY,Jung HY, Park KY,et al. Enhanced p62 expression through impaired proteasomal degradation is involved in caspase-1 activation in monosodium urate crystal-induced interleukin-1b expression [J]. Rheumatology(Oxford),2014,53(6):1043-1053.
[18] Terkeltaub R. What makes gouty inflammation so variable?[J]. BMC Med,2017,15(1):158.
[19] 杨虹,杨小红,钟晓武,等.辅助性T细胞17/调节性T细胞平衡在原发性痛风性关节炎发病机制中的作用[J].中华风湿病学杂志,2016,20(8):520-525.
[20] Rock KL,Kataoka H,Lai JJ. Uric acid as a danger signal in gout and its comorbidities [J]. Nat Rev Rheumatol,2013,9(1):13-23.
[21] Liu YF, Wen CY,Chen Z,et al. Effects of Berberine on NLRP3 and IL-1beta expressions in monocytic THP-1 cells with monosodium urate crystals-induced inflammation [J]. Biomed Res Int,2016,2016:2 503 703.
[22] Noack M,Miossec P. Selected cytokine pathways in rheumatoid arthritis [J]. Semin Immunopathol,2017,39(4):365-383.
[23] Malemud CJ. Negative regulators of JAK/STAT signaling in rheumatoid arthritis and osteoarthritis [J]. Int J Mol Sci,2017,18(3):484.
[24] Wang Z,Chen Z,Yang S,et al. Berberine ameliorates collagen-induced arthritis in rats associated with anti-inflammatory and anti-angiogenic effects [J]. Inflammation,2014,37(5):1789-1798.
[25] Huang M,Jiang X,Liang Y,et al. Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of beta-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease [J]. Exp Gerontol,2017,91:25-33.
[26] Yang Y,Wang Q,Xie M,et al. Berberine exerts an anti-inflammatory role in ocular Behcet's disease [J]. Mol Med Rep,2017,15(1):97-102.
[27] Choi SB,Bae GS,Jo IJ,et al. Berberine inhibits inflammatory mediators and attenuates acute pancreatitis through deactivation of JNK signaling pathways [J]. Mol Immunol,2016,74:27-38.
[28] Caliceti C,Franco P,Spinozzi S,et al. Berberine:new insights from pharmacological aspects to clinical evidences in the management of metabolic disorders [J]. Curr Med Chem,2016,23(14):1460-1476.
[29] Wang X,He X,Zhang CF,et al. Anti-arthritic effect of berberine on adjuvant-induced rheumatoid arthritis in rats [J]. Biomed Pharmacother,2017,89:887-893.