Evaluation value of immature granulocytes combined with SOFA score on prognosis in patients with sepsis
GUO Junchuan Mutalifu·Maihemuti XIAO Dong
The Second Department of Critical Care Medicine, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830000, China
Abstract：Objective To evaluate the value of immature granulocytes combined with sepsis related organ failure assessment (SOFA) score in the prognosis of patients with sepsis. Methods From October 2016 to December 2017, 88 patients with sepsis who were treated in People′s Hospital of Xinjiang Uygur Autonomous Region and met the inclusion and exclusion criteria were selected. After 28 days of observation, the patients were divided into survival group and death group. The acute physiology and chronic health evaluation (APACHEⅡ) score, SOFA score, clinical parameters related to disease severity, and procalcitonin (PCT), C-reactive protein (CRP), absolute value of immature granulocytes (IG#) and percentage of immature granulocytes (IG%) at admission were compared between the two groups. The ROC curve was used to compare IG#, IG%, SOFA score, and the value of combined detection in predicting the prognosis of sepsis. Results There were 56 cases in the final survival group and 32 cases in the death group. There were statistically significant differences between the two groups in APACHEⅡ score, SOFA score, septic shock, mechanical ventilation, mechanical ventilation time, vasoactive drugs and continuous renal replacement therapy (CRRT) (all P ＜ 0.05). IG% and IG# were positively correlated with SOFA scores (r = 0.630, 0.574, all P ＜ 0.001). ROC analysis showed that the area under the curve (AUC) of SOFA was significantly larger than IG# and IG%. The AUC of SOFA score combined with IG# and IG% was significantly larger than any other single indicator. Conclusion The immature granulocyte is a useful index to predict the prognosis of sepsis patients. Immature granulocytes combined with SOFA score detection has a higher sensitivity and specificity for the assessment of poor prognosis.
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2019, Vol. 16 
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