白细胞介素-8基因启动子-251T＞A多态性与急性胰腺炎发病风险的Meta分析

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摘要目的统计分析白细胞介素-8（IL-8）基因启动子-251T＞A多态性与急性胰腺炎（AP）发病风险的关系。方法对PubMed、Embase、Web of Science databases和万方数据库进行系统检索，检索IL-8启动子-251T＞A多态性和急性胰腺炎发病风险相关的文献，文献查找日期为1990年1月～2015年12月。结果最终有7篇文献共计2282例病例纳入本研究。其中AP组病例1013例，对照组病例1269例。在纳入的总体中，IL-8启动子-251T＞A多态性和AP发病风险相关（OR = 1.56，95%CI：1.14～2.13，P = 0.02）；在显性模型中，A基因携带者会增加AP发病风险（OR = 1.44，95%CI：1.21～1.73，P = 0.01）；在隐性模型中，纯合子AA基因型也会增加AP发病风险（OR = 1.65， 95%CI：1.13～2.41，P = 0.02）。亚组分析提示，IL-8启动子-251A多态性MAP隐性基因模型（OR = 2.01，95%CI：1.25～3.24，P = 0.025）和SAP所有基因模型（OR = 1.80，95%CI：1.43～2.26，P = 0.022；显性模型OR = 2.17，95%CI：1.54～3.06，P = 0.014；隐性模型OR = 2.39，95%CI：1.49～3.81，P = 0.005）会增加与AP发病风险。结论 IL-8基因启动子-251T＞A多态性可能会增加AP的发病风险。但是考虑到本研究的局限性，需要有设计更完善、样本量更大的研究来证实该结论。

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	刘建平栗粟孙雅轩

关键词 ：白细胞介素-8, 急性胰腺炎, 多态性, Meta分析

Abstract：Objective To investigate the relationship between the polymorphism of interleukin-8 (IL-8) gene promoter -251T＞A with the risk of acute pancreatitis (AP). Methods PubMed, Embase, Web of Science databases and WanFang were searched for studies on IL-8 promotor-251T＞A polymorphism and AP risk from January 1990 to December 2015. Results Finally, seven studies involving 2282 cases, among all the cases, 1013 in the AP group and 1269 in the control group. Among the population enrolled, IL-8 promoter-251T>A polymorphism was related to AP risk(OR = 1.56，95%CI: 1.41-2.13，P = 0.02). In the dominant models, A carrier increased AP risk (OR = 1.44，95%CI: 1.21-1.73，P = 0.01); in the recessive models, homozygote AA increased AP risk (OR = 1.65, 95%CI: 1.13-2.41, P = 0.02). Subgroup analysis indicated that the recessive gene model of MAP (OR = 2.01, 95% CI:1.25-3.24, P = 0.025) and all SAP gene models (OR = 1.80, 95% CI: 1.43-2.26, P = 0.022), the dominant model (OR = 2.17, 95% CI:1.54-3.06, P = 0.014) and the recessive model (OR = 2.39, 95% CI:1.49-3.81, P = 0.005) of IL-8 promoter-251T>A polymorphism increased the risk of AP. Conclusion IL-8 promoter-251T＞A is associated with increase of AP risk, but considering the limitations of this study, further research with better design and larger sample size is needed to confirm the conclusion.

Key words： Interleukin-8 Acute pancreatitis Polymorphism Meta-analysis

基金资助:四川省科技厅科技支撑计划项目（2014SZ03614）。

作者简介: 刘建平（1983.6-），男，硕士，副主任医师，主要从事肝胆外科的研究工作。

引用本文:

刘建平栗粟孙雅轩. 白细胞介素-8基因启动子-251T＞A多态性与急性胰腺炎发病风险的Meta分析[J]. 中国医药导报, 2019, 16(1): 68-73.
LIU Jianping LI Su SUN Yaxuan. Meta analysis of the polymorphism of interleukin-8 gene promoter -251T＞A with the risk of acute pancreatitis. 中国医药导报, 2019, 16(1): 68-73.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I1/68

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