Abstract:Objective To explore the application effect of situational interactive problem-based learning (PBL) in experimental course of pathology. Methods In March 2017, among 480 students of 8 clinical classes in 2016 grade of Zhaoqing Medical College, 120 students at two classes were randomly selected, 60 students of one class were given situational interactive PBL teaching method (experiment group), 60 students of another class were given traditional teaching method (control group). The effect of situational interactive PBL teaching was evaluated through experimental examination and questionnaire survey. Results The examination result of students in the experiment group was better than the control group, the difference was statistically significant (P < 0.01). The teaching effect of students in the experiment group was better than the control group, the differences were statistically significant (P < 0.05 or P < 0.01). Conclusion Situational interactive PBL teaching can fully inspire the initiative of learning, train students′ ability of clinical pathological thinking, improve the teaching effect of pathology experiment course.