Abstract：Objective The sesquiterpene component of Vladimiriae souliei was extracted, separated and purified, and made into a solid dispersion to increase its dissolution rate in vitro. Methods An ultra performance liquid chromatography method for the determination of the content of sesquiterpene in Vladimiriae souliei was established. The chromatographic conditions were Acquity ultra-high performance liquid chromatography. The column was a Waters BEH-C18 column (2.1 mm × 50 mm, 1.7 μm). The mobile phase was acetonitrile-water (50:50); the flow rate was 0.4 mL/min; the detection wavelength was 225 nm. The sesquiterpenes were extracted by ultrasound-assisted extraction and purified by silica gel column chromatography. The solid dispersions were prepared by using polyethylene glycol and poloxamer as carrier materials, and characterized by differential scanning calorimetry. Results The solid dispersions prepared by different carriers could obviously accelerate the dissolution of costunolide and dehydrocostuslactone. The solid dispersions prepared by using Poloxamer 188 (P188) as carrier had the fastest dissolution rate, and the best mass ratio of sesquiterpene components to P188 was 1∶6. Conclusion The solid dispersion of Vladimiriae souliei sesquiterpene component can significantly improve the solubility and dissolution rate of the drug.
2019, Vol. 16 
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