Research progress on the mechanism of osteopontin in promoting the invasion and metastasis of gastric cancer
QIN Yuechao1 YUAN Xiaolin1 QU Fanjie2
1.Central Laboratory, Affiliated Zhongshan Hospital of Dalian University, Liaoning Province, Dalian 116001, China;
2.Department of Oncology, the Third People′s Hospital of Dalian City, Liaoning Province, Dalian 116033, China
Abstract：Osteopontin (OPN) is a phosphorylated glycoprotein that is highly expressed in a variety of cancers, which has the effects of inhibiting tumor cell apoptosis and promoting tumor cell invasion and metastasis. In recent years, studies have demonstrated that OPN is overexpressed in gastric cancer and it can up-regulate the expression of various angiogenic factors and protein kinases through MAPK, NF-κB, PI3K/AKT signaling pathways, autocrine pathways, and macrophage polarization. The overexpression of OPN promotes the invasion and metastasis of gastric cancer cells. Therefore, OPN may become a new target for regulating the invasion and metastasis of gastric cancer cells. This paper analyzes and summarizes the mechanism of OPN in promoting the invasion and metastasis of gastric cancer, in order to provide reference for the treatment of OPN target of gastric cancer.
覃月超1 袁小林1 曲范杰2. 骨桥蛋白促胃癌侵袭转移机制的研究进展[J]. 中国医药导报, 2018, 15(36): 28-31,39.
QIN Yuechao1 YUAN Xiaolin1 QU Fanjie2. Research progress on the mechanism of osteopontin in promoting the invasion and metastasis of gastric cancer. 中国医药导报, 2018, 15(36): 28-31,39.
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2018, Vol. 15 
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