Abstract：Objective To observe the efficacy of endoscopic ligation combined with Carvedilol in the prevention of esophageal varices rebleeding. Methods A total of 126 patients with cirrhosis of esophageal varices treated in Xi'an Central Hospital from October 2016 to June 2017 were enrolled. The patients were divided into experimental group, control group A and control group B by random number table method with 42 cases in each group. The control group A was treated with endoscopic ligation alone. The control group B was treated with endoscopic ligation combined with Propranolol. The experimental group was treated with endoscopic ligation combined with Carvedilol. Oneyear follow-up was performed after operation. Clinical effect, rebleeding rate, Child-Pugh classification of liver function, esophageal varices classification, and spleen hardness were compared before and after treatment. Results The total effective rate of the experimental group was higher than that of the control group A and the control group B (P ＜ 0.05). The rebleeding rate in the experimental group was lower than that in the control group A and the control group B (P ＜ 0.05). One year postoperation, the Child-Pugh classification of liver function in the experimental group was better than that before treatment, and it was better than that in the control group A and the control group B (P ＜ 0.05). The grades of esophageal varices in the three groups all improved than those before treatment, and the experimental group was superior to the control group A and the control group B (P ＜ 0.05). The spleen hardness of the three groups were lower than those before treatment, and the experimental group was lower than that in the control group A and the control group B (P ＜ 0.05). Conclusion Endoscopic ligation combined with Carvedilol treating patients with cirrhosis of esophageal varices can enhance the efficacy, reduce rebleeding, improve liver function and esophageal varices, and reduce spleen stiffness.
2018, Vol. 15 
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