Relationship between left atrial diameter, high sensitivity C reactive protein, brain natriuretic peptide and non-valvar atrial fibrillation in elderly patients
ZHANG Lin1 CHEN Yanjiong1 WU Boyun2 LIU Junhui1 HONG Zhou2 LI Na3 FENG Jing1 TAO Dan1
1.Department of Laboratory, the First Affiliated Hospital of Xi′an Jiaotong University, Shaanxi Province, Xi′an 710061, China;
2.Department of Emergency, Xi′an NO5 Hospital, Shaanxi Province, Xi′an 710082, China;
3.Department of Obstetrics and Gynecology Department, the First Affiliated Hospital of Xi′an Jiaotong University, Shaanxi Province, Xi′an 710061, China
Abstract：Objective To investigate the relationship between left atrial diameter (LAD), high sensitivity C reactive protein (hsCRP), brain natriuretic peptide (BNP) and non-valvar atrial fibrillation in elderly patients. Methods A total of 103 elderly patients with non-valvular atrial fibrillation admitted to the First Affiliated Hospital of Xi′an Jiaotong University ("our hospital" for short) from February 2015 to December 2017 were enrolled as the study group; 90 patients with senile non-atrial fibrillation who had sinus rhythm in the same period were selected as the control group. According to the classification of atrial fibrillation, the study group was divided into paroxysmal (n = 28), persistent (n = 34), permanent (n = 41). Patients in the study group were divided into non-thrombotic group (n = 61) and thrombotic group (n = 42) according to whether there was thrombosis in the left atrium. The hsCRP, BNP and LAD of the patients with different atrial fibrillation, non-thrombosis and thrombosis groups were compared between the control group and the study group and the study group. Pearson analysis was used to analyze the correlation between hsCRP, BNP and LAD in the study group. Multivariate Logistic regression analysis was used to analyze the influencing factors of non-valvar atrial fibrillation. Results The hsCRP, BNP and LAD of the study group were higher than those of the control group (P < 0.05). Patients with permanent, persistent atrial fibrillation had higher hsCRP, BNP, and LAD than patients with paroxysmal atrial fibrillation, and patients with permanent atrial fibrillation were more likely to have persistent atrial fibrillation (P < 0.05). The levels of hsCRP, BNP and LAD in thrombotic group were higher than those in non-thrombotic group (P < 0.05). There was a positive correlation between LAD and hsCRP and BNP in the study group(r = 0.468, 0.517, all P ＜ 0.01). Multivariate Logistic regression analysis showed that hsCRP, BNP and LAD were influencing factors of non-valvar atrial fibrillation in elderly patients(P < 0.01). Conclusion HsCRP, BNP and LAD are closely related to the occurrence and development of non-valvar atrial fibrillation in elderly patients.
2018, Vol. 15 
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