糖视明胶囊对气阴两虚血瘀型糖尿病视网膜病变患者视力及生活质量的影响

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摘要目的观察糖视明胶囊对气阴两虚血瘀型糖尿病视网膜病变（DR）患者视力及生活质量的影响。方法本研究纳入的92例（184只眼）DR患者均来源于2017年2～8月就诊于山东中医药大学第二附属医院内分泌科、眼科病房及门诊的患者，应用随机数字表法随机分为试验组和对照组，其中试验组45例（90只眼），对照组47例（94只眼）。最终完成随访共80例DR患者，试验组和对照组各40例（80只眼），对照组给予控制血压、血糖、血脂及生活方式干预治疗，试验组在对照组的基础上给予中药糖视明胶囊口服，观察治疗前后两组生活质量、视力、中医症候积分、空腹血糖、餐后2 h血糖、糖化血红蛋白变化及安全性评价指标（血、尿常规、肝肾功能、心电图）。结果两组患者治疗前生活质量各维度得分比较，差异无统计学意义（P ＞ 0.05），治疗后两组生活质量评分均明显改善（P ＜ 0.05），且试验组改善程度大于对照组（P ＜ 0.05）。两组患者治疗前视力差异无统计学意义（P ＞ 0.05），治疗后两组视力均有提高（P ＜ 0.05），且试验组提高程度大于对照组（P ＜ 0.05）。两组患者治疗前症候积分比较差异无统计学意义（P ＞ 0.05），治疗后两组患者症候积分均降低（P ＜ 0.05），试验组低于对照组（P ＜ 0.05）。两组患者治疗前糖化血红蛋白、空腹血糖及餐后2 h血糖差异无统计学意义（P ＞ 0.05），治疗后此上述指标均明显降低（P ＜ 0.05），且试验组低于对照组（P ＜ 0.05）。试验组总有效率（82.50%）高于对照组（55.00%）（P ＜ 0.05）。两组患者治疗前后血、尿常规、肝肾功能均在正常范围，均未出现不良反应。结论糖视明胶囊可以明显改善DR患者的视力水平和生活质量，且安全性较好。

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	荣汶青1 滕涛2 黄延芹3 徐云生4

关键词 ：糖视明胶囊, 糖尿病视网膜病变, 生活质量

Abstract：Objective To observe the effect of Tangshiming Capsules on the visual acuity and quality of life in patients with diabetic retinopathy (DR) in TCM syndrome type of qi-yin deficiency and blood stasis. Methods Ninety two (184 eyes) DR cases admitted to the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine from February to August 2017 were selected from Ward and Outpatient of Departments of Endocrinology and Ophthalmology. They were divided into experimental group and control group by random number table method with 45 cases (90 eyes) in the experimental group and 47 cases in the control group (94 eyes). Eventually, eighty DR cases finished follow-up, with 40 cases (80 eyes) in each group. The control group was given the treatment of control blood pressure, blood glucose, blood lipids and lifestyle intervention. The experimental group was given Tangshiming Capsules orally on the basis of the treatment of the control group. Quality of life, visual acuity, TCM syndrome scores, fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin changes and safety evaluation indicators (blood routine, urine routine, liver and kidney function, electrocardiogram) were observed before and after treatment. Results Before treatment, there was no significant difference in the scores of quality of life between the two groups (P ＞ 0.05), which were all significantly improved after treatment (P ＜ 0.05), and the improvement in the experimental group was superior than the control group (P ＜ 0.05). Before treatment, there was no significant difference in visual acuity between the two groups (P ＞ 0.05), which both improved in the two groups after treatment (P ＜ 0.05), and the improvement in the experimental group was superior to the control group (P ＜ 0.05). Before treatment, there was no significant difference in the syndrome scores between the two groups (P ＞ 0.05), which both reduced after treatment in the two groups (P ＜ 0.05), and the scores was lower in the experimental group than the control group (P ＜ 0.05). There was no significant difference in glycosylated hemoglobin, fasting blood glucose, and postprandial blood glucose 2 h before treatment between the two groups (P ＞ 0.05), which all reduced significantly after treatment (P ＜ 0.05), and those in the experimental group was lower than the control group (P ＜ 0.05). The total effective rate was 82.50% in the experimental group, which was higher than 55.00% in the control group (P ＜ 0.05). Blood and urine routine, liver and kidney function were normal in both groups before and after treatment, and no adverse reactions occurred. Conclusion Tangshiming Capsules can significantly improve the visual acuity and quality of life of DR patients, and the security was good.

Key words： Tangshiming Capsules Diabetic retinopathy Quality of life

基金资助:山东省科技惠民计划（2014kjhm0106）；
泰山学者工程专项经费资助（ts201712097）。

通讯作者: 徐云生（1965.1-），男，博士后，主任医师，教授，博士生导师，山东中医药大学第二附属医院院长；研究方向：中医药治疗内分泌疾病。

作者简介: 荣汶青（1992.10-），女，山东中医药大学第一临床医学院2016级中医内科学专业硕士研究生；研究方向：中医药治疗内分泌疾病。

引用本文:

荣汶青1 滕涛2 黄延芹3 徐云生4. 糖视明胶囊对气阴两虚血瘀型糖尿病视网膜病变患者视力及生活质量的影响[J]. 中国医药导报, 2018, 15(34): 118-121,134.
RONG Wenqing1 TENG Tao2 HUANG Yanqin3 XU Yunsheng4. Effect of Tangshiming Capsules on visual acuity and quality of life in patients with diabetic retinopathy in TCM syndrome type of qi-yin deficiency and blood stasis. 中国医药导报, 2018, 15(34): 118-121,134.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I34/118

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