Contrastive study of the effect of Rocuronium Bromide and Cisatracurium Besilate on hemodynamics and stress response in patients with radical mastectomy of breast cancer
JIANG Liuqin JIN Le LU Yanbin
Department of Anesthesiology, No.215 Hospital of Shaanxi Nuclear Industry, Shaanxi Province, Xianyang 712000, China
Abstract：Objective To compare the effect of Rocuronium Bromide and Cisatracurium Besilate on anesthesia induction in patients with radical mastectomy of breast cancer. Methods A total of 97 patients who received radical mastectomy for breast cancer in NO.215 Hospital of Shaanxi Nuclear Industry from March 2015 to March 2018 were selected as study objects. According to the methods of anesthesia induction, patients were divided into research group (45 cases) and control group (52 cases). The anesthesia induction drug of the research group was Rocuronium Bromide, and the anesthesia induction drug of the control group was Cisatracurium Besilate. The anesthesia effect time, anesthesia time, tracheal extubation time were compared between the two groups; levels of hemodynamics, stress related index before anesthesia induction (T1), after anesthesia induction (T2), and the time of 3 min after laryngeal mask placement (T3) were compared between the two groups respectively; the adverse reactions of two groups were observed. Results The effective time of anesthesia in the research group was significantly lower than the control group, while the duration of anesthesia and the duration of trachea extubation were significantly higher than the control group (P < 0.05). At T2 and T3, the mean arterial and heart rate of the research group were significantly lower than the control group (P < 0.05). The levels of epinephrine and norepinephrine in the research group at T2 and T3 were significantly lower than the control group (P < 0.05 or P < 0.01). The incidence of adverse reactions in the research group was 8.89%, which was significantly lower than 28.85% of the control group (P < 0.05). Conclusion Compared with Cisatracurium Besilate, Rocuronium Bromide is more effective in induction of anesthesia for patients with radical mastectomy of breast cancer, which is beneficial to maintain hemodynamic stability, relieve stress reaction and reduce the occurrence of adverse reactions, which is worthy of clinical application.
蒋留琴 靳乐 鲁彦斌. 罗库溴铵与顺苯磺酸阿曲库铵对乳腺癌根治术患者血流动力学及应激反应影响的对比研究[J]. 中国医药导报, 2018, 15(34): 102-105.
JIANG Liuqin JIN Le LU Yanbin. Contrastive study of the effect of Rocuronium Bromide and Cisatracurium Besilate on hemodynamics and stress response in patients with radical mastectomy of breast cancer. 中国医药导报, 2018, 15(34): 102-105.
[1] Archana A，Sureshkumar S，Vijayakumar C，et al. Comparing the harmonic scalpel with electrocautery in reducing postoperative flap necrosis and seroma formation after modified radical mastectomy in carcinoma breast patients：a double-blind prospective randomized control trail [J]. Cureus，2018，10（4）：2476-2477.
[2] Matsumoto M，Flores EM，Kimachi PP，et al. Benefits in radical mastectomy protocol： a randomized trial evaluating the use of regional anesthesia[J]. Sci Rep，2018，8（1）：7815-7815.
[3] 杨宝锋，王婕，李长生，等.乳腺癌患者术前睡眠质量对围术期丙泊酚和瑞芬太尼用量的影响[J].中国实用医刊，2016，43（15）：23-25.
[4] 周瑜，刘珊珊，张珏颢，等.顺式阿曲库铵与维库溴铵用于乳腺癌改良根治术患者的麻醉效果及对诱导期应激反应的影响[J].现代生物医学进展，2017，17（35）：6869-6872.
[5] 宋涛，曾祥刚，李星宇，等.术前化疗对乳腺癌患者术中顺苯磺阿曲库铵肌松效应的影响[J].贵州医药，2014，33（9）：822-824.
[6] 张曦，张丽.帕瑞昔布钠在乳腺癌患者围术期应用的镇痛效果及不良反应[J].山东医药，2013，53（33）：66-68.
[7] El Mourad MB，Amer AF. Effects of adding dexamethasone or ketamine to bupivacaine for ultrasound-guided thoracic paravertebral block in patients undergoing modified radical mastectomy： a prospective randomized controlled study [J]. Indian J Anaesth，2018，62（4）：285-291.
[8] Chen D，Wang H，Song X，et al. A prognostic score model to determine which breast cancer patients with 1-3 positive lymph nodes after modified radical mastectomy should receive radiotherapy [J]. Oncotarget，2017，9（1）：385-393.
[9] 冯娅妮，朴春梅，孙艳红，等.不同浓度右美托咪定对罗库溴铵肌松效应的影响[J].中国医师杂志，2014，16（10）：1346-1348.
[10] 王晓青，柯文举，祝胜美，等.右美托咪定与芬太尼预防乳腺癌根治术患者七氟烷麻醉术后躁动的作用[J].中国老年学杂志，2016，36（14）：3509-3510.
[11] 杨海扣，周静，拾翠翠，等.右美托咪定复合罗哌卡因在乳腺癌术后镇痛中的应用[J].广东医学，2017，38（3）：466-467.
[12] Chavan RN，Chikkala B，Mondal P，et al. Comparison study between scalpel and electrocautery，in causation of seroma after modified radical mastectomy [J]. Indian J Surg，2017，79（5）：423-426.
[13] 江培颜.全身麻醉诱导应用丙泊酚联合依托咪酯对顺苯磺酸阿曲库铵药效学的影响[J].中外医学研究，2017， 15（16）：25-27.
[14] 张晓梅，王国林，丁梅，等.小儿亲属活体部分肝移植术中应用顺苯磺酸阿曲库铵和维库溴铵的麻醉效果评价[J].中华器官移植杂志，2017，38（4）：225-228.
[15] 孟宏伟，殷小坤.罗库溴铵与顺苯磺酸阿曲库铵对乳腺癌改良根治术患者麻醉效果及诱导期应激反应的影响研究[J].中国肿瘤外科杂志，2018，10（1）：41-43.
[16] 吴德华，马静雅，徐益萍，等.不同麻醉方法下胸科手术老年病人术中房颤发生的比较：大样本临床研究[J].中华麻醉学杂志，2017，37（1）：34-38.
[17] 郑育秀，徐志新，黄泽波，等.不同肌松药对乳腺癌患者麻醉诱导期应激反应的影响[J].西南国防医药，2016， 26（11）：1262-1265.
[18] 包娜日素，韩亚升，张生茂，等.胃癌根治术不同浓度右美托咪定对罗库溴铵肌松起效时间及临床时效的影响[J].实用癌症杂志，2017，32（1）：90-93.
[19] 程芳.米库氯铵与罗库溴铵用于麻醉诱导时插管的临床疗效观察[J].中国医药指南，2018，16（1）：17-18.
[20] 黄建强，王宏梗，黄方，等.两种肌松药在小儿气道异物取出术中的疗效分析[J].中山大学学报：医学科学版，2017，38（4）：569-575.
[21] 吴振华.罗库溴铵对良、恶性肿瘤患者肌松时间的影响[J].中国基层医药，2017，24（21）：3274-3277.
[22] 朱敦.罗库溴铵与维库溴铵在全麻诱导期抑制咳嗽反应的效果比较[J].河北医学，2016，22（5）：745-747.
2018, Vol. 15 
京公网安备 11010502046598号