Association of iron overload with disease related indexes in non-diabetic patients with non-alcoholic fatty liver disease
WU Xianbin1 SU Dongxing1 LIANG Yi2 PANG Lixing1 LIANG Xiaolan1 LIU Caijin1 CHEN Qingzhou1 WEI Yujuan3 ZHANG Tingzheng4
1.Department of Gastroenterology, the Third Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530031, China; 2.Department of Cardiovascular, the Third Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530031, China; 3.Department of Ultrasonography, the Third Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530031, China; 4.Department of Parasitology, Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530031, China
Abstract：Objective To investigate the association between iron overload and non-alcoholic fatty liver disease (NAFLD) in non-diabetic patients. Methods From January 2016 to December 2017, 152 patients with NAFLD who were not Complicated with diabetes enrolled in the Third Affiliated Hospital of Guangxi Medical University (“our hospital” for short) were selected as the observation group. Eighty healthy subjects udertaking phylical examination in our hospital were selected as the control group. Their general data, biochemical indicators, serum ferritin (SF), serum iron (SI) and serum hepcidin (HEPC) were recorded or detected, liver fat content (LFC) was evaluated by proton magnetic resonance spectroscopy. The relationships between the indexes of iron overload and other indexes were analyzed. Results SF and SI in the observation group were significantly higher than those in the control group, and HEPC was significantly lower than that in the control group, the differences were statistically significant (P ＜ 0.05). After adjustment for age and sex, both SF and SI had linear positive correlations with LFC (r = 0.461, P ＜ 0.001; r = 0.275, P = 0.001), and HEPC had a significant linear negative correlation with LFC (r = -0.479, P ＜ 0.001). The increase of SI was an independent risk factor for liver damage (OR = 1.074, P ＜ 0.05, 95%CI = 1.022-1.130). SF, SI, HEPC were weakly correlated with NAFLD activity scores (r = 0.172, P = 0.036; r = 0.192, P = 0.019; r = -0.236, P = 0.004), but the correlation coefficients were too low, which may lacked clinical significance. Conclusion Iron overload in non-diabetic patients is related to the increase of LFC and liver function damage, but it has no correlation with the degree of liver inflammation.
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2018, Vol. 15 
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