Abstract：Objective To explore the application of animal models of renal interstitial fibrosis in experimental teaching of gene regulation. Methods From September 2016 to September 2017, 60 undergraduate students from 2012 and 2013 medical biotechnology majors in Army Military Medical University were selected as the research subjects. The students were randomly divided into two groups, 30 students in each group. The conventional method was used in the control group for gene regulation experiment teaching, while the renal interstitial fibrosis animal model to carry out gene control experiment teaching was used in observation group. Then rated the teaching situation of teachers and students in two groups, students′ final exam results and students′ evaluation of teaching effect. Results The scores of teaching process, teaching guidance and teaching effect of teachers and students in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05 or P < 0.01). The scores of theoretical examination and practical skill examination in the observation group were higher than those in the control group, the differences were highly statistically significant (P < 0.01). The students′ overall impression of teaching methods, cultivation of experimental practical ability, students′ good grasp of theoretical knowledge through experimental courses, experimental ability to cultivate students′ innovative thinking, cultivate students′ team cooperation ability, and the satisfaction rate of accepted teaching methods in the observation group were higher than those in the control group, the differences were highly statistically significant (P < 0.01). Conclusion The application of animal models of renal interstitial fibrosis in experimental teaching of gene regulation can improve students′ interest in learning and academic performance, and improve teaching quality.
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2018, Vol. 15 
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