Abstract：Objective To study the risk and influencing factors of thrombosis in patients with early diabetic nephropathy. Methods One hundred and twenty patients with type 2 diabetes that admitted to Endocrinology Department of Cangzhou Hospital of Integrated Chinese and Western Medicine("our hospital" for short) from May 2017 to May 2018 were selected, with 60 cases ACR<2.5 (male)/3.5 (female) mg/mmol as type 2 diabetes group (T2DM group), 60 cases ACR from 2.5 (male)/3.5 (female) mg/mmol to 30.0 mg/mmol as early diabetic nephropathy group (EDN group). And 30 cases of health check-up in our hospital were taken as the control group（NC group）. The metabolism indexes of each group were detected as fasting blood-glucose (FPG), postprandial 2 h plasma glucose (2hPBG), glycosylated hemoglobin (HbA1c), total cholestero (TC), low-density lipoprotein cholesterol (LDL-C), triacylglycerol (TG), and thrombelastogram (TEG) indexes as R value, K value, CI value, MA value, Angle angle value to assess the risk of thrombosis. Results Compared with the NC group, the levels of FPG, 2hPBG, HbA1c of T2DM group and EDN group increased (P ＜ 0.05); compared with the T2DM group, the levels of FPG, 2hPBG, HbA1c of EDN group increased (P ＜ 0.05). Compared with the NC group, the levels of TG, TC, LDL-C of T2DM group and EDN group increased (P ＜ 0.05), while there was no significant difference in the levels of TG, TC, LDL-C between T2DM group and EDN group (P ＞ 0.05). Compared with the NC group, the R value and K value of T2DM group and EDN group decreased, while the Angle value, MA value and CI value increased, and the differences were statistically significant (P < 0.05); compared with the T2DM group, the R value and K value of the EDN group decreased, while the Angle value, MA value and CI value increased, the differences were statistically significant (P < 0.05). Linear correlation analysis showed that ACR was negatively correlated with R value and K value (r = -0.423, -0.517, all P < 0.01), ACR was positively correlated with Angle value, MA value and CI value (r = 0.683, 0.742, 0.669, all P < 0.01). Logistic regression analysis showed that the course of diabetes, dyslipidemia, smoking history, and ACR increase were independent risk factors for thrombosis in patients with early diabetic nephropathy (OR = 2.423, 1.986, 2.103, 4.358, all P < 0.05). Conclusion Diabetics have a higher risk of blood clots than healthy adults before proteinuria. Patients with early diabetic nephropathy have a higher risk of thrombosis than those with simple diabetes. The risk of thrombosis in patients with diabetic nephropathy is related to the course of diabetes, smoking history, dyslipidemia, and elevated ACR.
苏阳 张倩 崔荣岗 李娟 田风胜. 早期糖尿病肾病患者血栓风险分析[J]. 中国医药导报, 2018, 15(33): 47-50.
SU Yang ZHANG Qian CUI Ronggang LI Juan TIAN Fengsheng. Risk analysis of thrombosis in early diabetic nephropathy patients. 中国医药导报, 2018, 15(33): 47-50.
2018, Vol. 15 
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