Abstract：Arctigenin (ARC-G) is an effective active ingredient of traditional Chinese medicine Arctii Fructus. In recent years, it has been confirmed by scholars that it has a variety of pharmacological effects, such as anti-inflammatory, immunomodulatory, anti-virus, anti-tumor activity, and it also has a certain effect on diabetic nephropathy and some neurodegenerative diseases. This article reviews a large number of domestic and foreign literatures in recent years, systematically analyzes the various pharmacological effects and mechanisms of action of ARC-G, highlights the influence of ARC-G on tumor cells, provides a theoretical basis for the further studies and clinical application of ARC-G.
王哲 王佳贺. 牛蒡子苷元药理作用的研究进展[J]. 中国医药导报, 2018, 15(32): 50-53.
WANG Zhe WANG Jiahe. Advances in studies on pharmacological effect of arctigenin. 中国医药导报, 2018, 15(32): 50-53.
[1] Newman DJ，Cragg GM. Natural Products as Sources of New Drugs from 1981 to 2014 [J]. J Nat Prod，2016，79（3）：629-661.
[2] 武世豪，杜金行，努尔比亚·阿布拉，等.牛蒡药理作用研究进展[J].中华中医药杂志，2017，32（7）：3093-3095.
[3] Nose M，Fujimoto T，Takeda T，et al. Structural transformation of lignan compounds in rat gastrointestinal tract [J]. Planta Med，1992，58（6）：520-523.
[4] Han F，Xia XX，Dou M，et al. Arctigenin：A two-edged sword in ischemia/reperfusion induced acute kidney injury [J]. Biomed Pharmacother，2018，103：1127-1136.
[5] Sun Y，Tan YJ，Lu ZZ，et al. Arctigenin Inhibits Liver Cancer Tumorigenesis by Inhibiting Gankyrin Expression via C/EBPα and PPARα [J]. Front Pharmacol，2018，9：268.
[6] Gao Q，Yang M，Zuo Z. Overview of the anti－inflammatory effects，pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L [J]. Acta Pharmacol Sin，2018，39（5）：787-801.
[7] Zhang H，Zhao Z，Wang T，et al. Inhibition of UDP-Glucuronosyltransferase（UGT）Isoforms by Arctiin and Arctigenin [J]. Phytother Res，2016，30（7）：1189-1196.
[8] Li P，Tompkins RG，Xiao W. KERIS：kaleidoscope of gene responses to inflammation between species [J]. Nucleic Acids Res，2017，45（D1）：D908-D914.
[9] Wu X，Yang Y，Dou Y，et al. Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L.fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice [J]. Int Immunopharmacol，2014，23（2）：505-515.
[10] Shi X，Sun H，Zhou D，et al. Arctigenin attenuates lipop-olysaccharide-induced acute lung injury in rats [J]. Inflammation，2015，38（2）：623-631.
[11] Zhang WZ，Jiang ZK，He BX，et al. Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK，HO-1，and iNOS Signaling [J]. Inflammation，2015，38（4）：1406-1414.
[12] 薛芳喜，姚景春，刘奋.牛蒡子苷元对小鼠免疫功能的影响[J].中华中医药学刊，2016，34（2）：350-352.
[13] Chen JH，Lam HY，Yip CC，et al. Evaluation of the molecular Xpert Xpress Flu/RSV assay vs. Alere i Influenza A & B assay for rapid detection of influenza viruses [J]. Diagn Microbiol Infect Dis，2018，90（3）：177-180.
[14] 郭琦，廖国阳.人用H7N9禽流感疫苗的研究进展[J].中国生物制品学杂志，2017，30（2）：210-214.
[15] Hayashi K，Narutaki K，Nagaoka Y，et al. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus [J]. Biol Pharm Bull，2010，33（7）：1199-1205.
[16] 李敏，林俊.细胞凋亡途径及其机制[J].国际妇产科学杂志，2014，41（2）：103-107.
[17] 王静泓，姜孝新，曾乐平，等.牛蒡子苷元通过抑制PI3-K/Akt信号通路诱导肝癌细胞凋亡[J].肿瘤药学，2015，5（6）：430-435.
[18] Wang HQ，Jin JJ，Wang J. Arctigenin enhances chemosensitivity to cisplatin in human nonsmall lung cancer H460 cells through downregulation of survivin expression [J]. J Biochem Mol Toxicol，2014，28（1）：39-45.
[19] Huang K，Li LA，Meng YG，et al. Arctigenin promotes apoptosis in ovarian cancer cells via the iNOS/NO/STAT3/survivin signaling [J]. Basic Clin Pharmacol Toxicol，2014，115（6）：507-511.
[20] Wang P，Solorzano W，Diaz T，et al. Arctigenin inhibits prostate tumor cell growth in vitro and in vivo [J]. Cancer Res，2017，77（s13）：1-11.
[21] 李孝庆，杨瑞仪，刘抗伦，等.牛蒡子苷与苷元诱导人前列腺癌PC3细胞非凋亡性死亡的研究[J].广州中医药大学学报，2013，30（4）：537-541.
[22] 何凡，孙小玲，宿亚柳，等.牛蒡子苷元抗肿瘤血管生成作用研究[J].中药药理与临床，2014，30（4）：19-23.
[23] Lou C，Zhu Z，Zhao Y，et al. Arctigenin，a lignan from Arctium lappa L.，inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/-9 and heparanase in MDA-MB-231 cells [J]. Oncol Rep，2017，37（1）：179-184.
[24] Sun PL，Jin Y，Kim H，et al. Survivin expression is an independent poor prognostic marker in lung adenocarcinoma but not in squamous cell carcinoma [J]. Virchows Arch，2013，463（3）：427-436.
[25] 王焕勤，王静.Survivin基因在牛蒡子苷元增强人肺癌H460细胞化疗敏感性中的作用[J].国际呼吸杂志，2015，35（6）：401-405.
[26] 赵慧玲，高彦彬.针刺治疗糖尿病性周围神经病变的临床观察[J].中国病毒病杂志，2001，3（3）：137-140.
[27] 马松涛，刘冬恋，牛锐，等.牛蒡子苷治疗糖尿病肾病的随机双盲安慰剂多中心Ⅲ期临床试验[J].中国临床药理学杂志，2011，27（1）：15-18.
[28] 李汶娟，王桂霞，王秀军，等.中药牛蒡对蛋白非酶糖化、肿瘤坏死因子α的影响及防治糖尿病肾病的作用[J].中国当代医药，2010，17（3）：9-10.
[29] Rocha Sobrinho HMD，Silva DJD，Gomides LF，et al. TLR4 and TLR2 activation is differentially associated with age during Parkinson′s disease [J]. Immunol Invest，2018，47（1）：71-88.
[30] Rocha NP，Assis F，Scalzo PL，et al. Reduced Activated T Lymphocytes（CD4+CD25+）and Plasma Levels of Cytokines in Parkinson′s Disease [J]. Mol Neurobiol，2018， 55（2）：1488-1497.
[31] Sun H. Association of soil selenium，strontium，and magnesium concentrations with Parkinson′s disease mortality rates in the USA [J]. Environ Geochem Health，2018， 40（1）：349-357.
[32] Monti C，Colugnat I，Lopiano L，et al. Network Analysis Identifies Disease-Specific Pathways for Parkinson′s Disease [J]. Mol Neurobiol，2018，55（1）：370-381.
[33] 李东薇，窦德强.牛蒡苷和牛蒡苷元抗帕金森活性的初步研究[J].中国现代医药杂志，2015，17（4）：20-22.
[34] Qi Y，Dou DQ，Jiang H，et al. Arctigenin Attenuates Learning and Memory Deficits through PI3k/Akt/GSK-3β Pathway Reducing Tau Hyperphosphorylation in Aβ-Induced AD Mice [J]. Planta Med，2017，83（1/2）：51-56.
2018, Vol. 15 
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