RUNX3（rs760805）基因多态性与胃癌发病风险的Meta分析

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摘要目的系统评价Runt相关转录因子3（RUNX3）（rs760805）基因多态性与胃癌发病风险的相关性。方法计算机检索数据库PubMed、EMbase、The Cochrane Library（2018年3期）、CMB、CNKI、VIP、Wanfang data，检索时间为建库到2018年3月，筛选关于RUNX3基因多态性与胃癌相关性的病例对照研究，语言限定为中文与英文。由两位评价员独立筛选文献，提取资料并评价纳入研究的偏倚风险，使用Newcastle-Ottawa量表（NOS）评价研究质量。对RUNX3（rs760805）各基因型模型进行比较，包括A与T、AA与TT、AA与TA+TT、TA与TT、AA+TA与TT，综合分析其在病例组和对照组中的分布情况。通过Q检验和I2值分析各研究间的异质性，应用Egger′s回归法验证评估发表偏倚，采用Stata 12.0软件进行Meta分析，计算比值比（OR）及95%置信区间（95%CI），评估RUNX3（rs760805）基因多态性与胃癌发病风险的相关性。结果本研究共纳入5项病例对照研究，共有1363例胃癌患者及1346例健康对照。Meta分析结果显示：RUNX3（rs760805）基因多态性与胃癌发病风险有关[A vs. T：OR = 1.27，95%CI（1.01， 1.59），P = 0.039；AA+TA vs. TT：OR = 1.30，95%CI（0.96，1.77），P = 0.091；AA vs. TT+TA：OR = 1.18，95%CI（0.99， 1.41），P = 0.073；AA vs. TT：OR = 1.51，95%CI（0.97，2.33），P = 0.065；TA vs. TT：OR = 0.73，95%CI（0.32，1.63），P = 0.437]。结论 RUNX3（rs760805）基因多态性与胃癌发病风险之间具有相关性，且等位基因A可能是胃癌的潜在危险因素。

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	朱晓芸1* 马如超2* 于红刚1

关键词 ：胃癌, Runt相关转录因子3, 基因多态性, 发病风险, 系统评价, Meta分析

Abstract：Objective To systematically evaluate the association between rs760805 polymorphism in Runt-related transcription factor 3 (RUNX3) gene and risk of gastric cancer. Methods PubMed, EMbase, The Cochrane Library (Issue 3, 2018), CMB, CNKI, VIP and Wanfang databases were searched, retrieval time form creating database to March 2018, the data of case-control studies on the correlation between polymorphisms of RUNX3 gene and risk of gastric cancer were retrieved, the language was limited to Chinese and English. Two evaluators independently screened literature, extracted data and evaluated the bias risk of included studies, and used Newcastle-Ottawa scale (NOS) to evaluate research quality. All genotype models of RUNX3 (rs760805) were compared, including A and T, AA and TT, AA and TA+TT, TA and TT, AA+TA and TT, and their distribution in case group and control group was comprehensively analyzed. Q-test and I2 value were used to analyze the heterogeneity among the studies, egger′s regression was used to verify the evaluation of publication bias, and Stata 12.0 software was used for Meta-analysis. The correlation of RUNX3 (rs760805) gene polymorphism with the risk of gastric cancer was calculated by using the odds ratio (OR) and 95% confidence interval (95%CI). Results A total of 5 case-control studies were included (gastric cancer cases: 1363, healthy controls: 1346). The results of Meta-analysis showed that (rs760805) polymorphism in RUNX3 gene was associated with risk of gastric cancer [A vs. T: OR = 1.27, 95%CI (1.01, 1.59), P = 0.039; AA+TA vs. TT: OR = 1.30, 95%CI (0.96, 1.77), P = 0.091; AA vs. TT+TA: OR = 1.18, 95%CI (0.99, 1.41), P = 0.073; AA vs. TT: OR = 1.51, 95%CI (0.97, 2.33), P = 0.065; TA vs. TT: OR = 0.73, 95%CI (0.32, 1.63), P = 0.437]. Conclusion There is a correlation between the genetic polymorphism of RUNX3 (rs760805) and the risk of gastric cancer, and allele A may be a potential risk factor for gastric cancer.

Key words： Gastric cancer Runt-related transcription factor 3 Gene polymorphism Onset risk Systematic evaluation Meta-analysis

基金资助:国家自然科学基金资助项目（81272693）。

通讯作者: 于红刚（1968.6-），男，博士，博士后，博士生导师，教授，主任医师；研究方向：消化道肿瘤与消化内镜研究，消化道早期肿瘤的诊断与治疗。

作者简介: 朱晓芸（1991.10-），女，武汉大学第一临床学院2016级内科学专业在读硕士研究生；研究方向：消化道肿瘤的预防、早期诊断及治疗。马如超（1992.5-），男，山东大学齐鲁医学院2016级内科学专业在读硕士研究生；研究方向：基因与疾病。 *共同第一作者

引用本文:

朱晓芸1* 马如超2* 于红刚1. RUNX3（rs760805）基因多态性与胃癌发病风险的Meta分析[J]. 中国医药导报, 2018, 15(29): 82-87.
ZHU Xiaoyun1* MA Ruchao2* YU Honggang1. Meta analysis on rs760805 polymorphism in RUNX3 gene and risk of gastric cancer. 中国医药导报, 2018, 15(29): 82-87.

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