Meta analysis on clinical efficacy and safety of Yangxinshi Tablets in the treatment of patients with coronary heart disease and angina pectoris
ZHU Xiule1 LI Yiping2 WANG Xiaolong1 GAO Junjie1
1.Department of Cardiovascular, Affiliated Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
2.Institute of Cardiovascular Disease, Affiliated Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Abstract：Objective To systematically evaluate the clinical efficacy and safety of Yangxinshi Tablets in the treatment of patients with coronary heart disease and angina pectoris. Methods Databases included CNKI, VIP, CBM, PubMed, and Cochrane Library, etc. The retrieval objects covered both Chinese and English references at home and abroad. The retrieval time limit was from inception to December 2017. Eligibility studies were screened to assess the quality of literatures, and relevant data was statistically analyzed by means of heterogeneity test, meta analysis and sensitivity analysis. Results A total of 13 studies including 1435 cases were enrolled, and the literature quality was relatively low. Meta-analysis results showed that compared with control group, combined application of Yangxinshi Tablets could improve the efficacy of angina pectoris [OR = 3.93, 95%CI (2.51-6.16), P < 0.000 01], ECG efficacy [OR = 2.46, 95%CI (1.69-3.59), P < 0.000 01], and reduce serum total cholesterol [WMD = 0.76, 95%CI (0.23-1.29), P = 0.005], triglyceride [WMD = 0.77, 95%CI (0.20-1.34), P = 0.008], low density lipoproteins [WMD = 1.85, 95%CI (1.77-1.92), P < 0.000 01], hypersensitive C-reactive protein [WMD = 1.23, 95%CI (0.25-2.21), P = 0.01] significantly. During the study, there were total 12 cases with stomach discomfort, most of the studies did not show significant abnormalities in biochemical indicators in liver and kidney function. Conclusion Compared with the single application of the basic treatment of Western medicine, Yangxinshi Tablets can further improve the clinical efficacy of patients with coronary heart disease and angina pectoris, with good safety.
朱修乐1 李益萍2 王肖龙1 高俊杰1. 养心氏片治疗冠心病心绞痛患者临床效果及安全性的Meta分析[J]. 中国医药导报, 2018, 15(28): 120-124,129.
ZHU Xiule1 LI Yiping2 WANG Xiaolong1 GAO Junjie1. Meta analysis on clinical efficacy and safety of Yangxinshi Tablets in the treatment of patients with coronary heart disease and angina pectoris. 中国医药导报, 2018, 15(28): 120-124,129.
2018, Vol. 15 
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