Abstract：Objective To compare the antiviral effect of Entecavir (ETV) and Tenofovir Disoproxil Fumarate (TDF) in initial treatment patients with chronic hepatitis B and liver cirrhosis. Methods A total of 80 initial treatment patients with chronic hepatitis B and liver cirrhosis who received antiviral therapy with TDF or ETV and were regularly followed up in the FAW General Hospital, from January 2016 to January 2017 were enrolled, and 38 patients were treated with TDF (TDF group) and 42 patients were treated with ETV (ETV group). Laboratory markers were measured before and at 24th, 36th, and 48th week of treatment, including liver and renal function parameters, serum calcium, serum phosphate, creatine kinase, HBV DNA level, hepatitis markers. Adverse drug reactions were also observed. Results At 24th week of treatment, HBsAg of ETV group was lower than that of TDF group (P ＜ 0.05). At 36th, 48th week of treatment, there was no difference in HBsAg of the two groups (P ＞ 0.05). At 24th, 36th, 48th week of treatment, the two groups had no statistical difference in ALT level (P ＞ 0.05). At 24th, 36th week of treatment, HBV DNA level of ETV group was lower than that of TDF group (P ＜ 0.05). At 48th week of treatment, HBV DNA level, proportion of HBeAg positive patients with HBV DNA level below floor level, rate of HBeAg turning negative, rate of HBeAg negative and positive patients with ALT turning normal in the two groups had no statistically difference (P ＞ 0.05). In TDF group, 2 cases occured serum inorganic phosphorus declined slightly, and bone mineral density was detected mild osteoporosi. Conclusion At 24th and 36th week of treatment, ETV restrains HBV DNA better than TDF, while at 48th week there is no differece between the two drugs.
申恩华 王茉莉 王立红 李欣杉 袁艺萌 陈鹏 袁静 张晶芬 付广双▲. 恩替卡韦和富马酸替诺福韦二吡呋酯治疗慢性乙型肝炎及乙型肝炎肝硬化抗病毒效果[J]. 中国医药导报, 2018, 15(28): 70-73.
SHEN Enhua WANG Moli WANG Lihong LI Xinshan YUAN Yimeng CHEN Peng YUAN Jing ZHANG Jingfen FU Guangshuang▲. Antiviral effect of Entecavir versus Tenofovir Disoproxil Fumarate in the treatment of chronic hepatitis B and liver cirrhosis. 中国医药导报, 2018, 15(28): 70-73.
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2018, Vol. 15 
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