miR-150在肿瘤发生发展中作用机制研究进展

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摘要微小RNA（miRNA）是一类长度为19~25个核苷酸的非编码小分子RNA，可在转录后水平影响细胞增殖、分化、凋亡等生物学功能，在肿瘤发生发展中起着重要调节作用。近年来，研究发现microRNA-150（miR-150）在大肠癌、肺癌及胰腺癌等恶性肿瘤中表达异常，并通过多种分子机制促进肿瘤细胞的增殖、侵袭及转移。因此，miR-150有望成为肿瘤精准诊断和治疗的候选分子标志物。本文通过对miR-150在不同肿瘤中生物学作用进行综述，进而为其临床转化提供理论依据和新思路。

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	屈潇1 秦环龙2

关键词 ： miR-150, 肿瘤, 分子诊断, 预后, 靶向治疗

Abstract：MicroRNA (miRNA) is defined as one kind of small endogenous noncoding RNA with a length of 19-25 nucleotides. At the post-transcriptional level, miRNA can influence the biological function of cell proliferation, differentiation, apoptosis etc. Also, miRNA plays an important role in regulating the development of tumor and chronic disease. The recent studies have shown that microRNA-150 (miR-150) abnormally expressed in all kinds of malignant tumors involving colon, lung and pancreas. Through a variety of molecular mechanisms, miR-150 can promote tumor cell proliferation, invasion and metastasis. Therefore, miR-150 is expected to be a candidate marker for accurate diagnosis and treatment of tumors. This article will review the biological role of miR-150 in different tumors, thus providing theoretical basis and new opinions to its clinical transformation.

Key words： Mir-150 Tumor Diagnosis Prognosis Treatment

基金资助:国家自然科学基金项目（81230057、81472262）。

通讯作者: 秦环龙（1965.11-），男，博士，教授，同济大学附属第十人民医院院长；研究方向：大肠癌与肠道微生态。

作者简介: 屈潇（1990.1-），女，安徽医科大学上海临床学院2016级普外科在读硕士研究生；研究方向：大肠癌与肠道微生态。

引用本文:

屈潇1 秦环龙2. miR-150在肿瘤发生发展中作用机制研究进展[J]. 中国医药导报, 2017, 14(32): 19-22.
QU Xiao1 QIN Huanlong2. The research of miR-150 in tumordevelopment and progression. 中国医药导报, 2017, 14(32): 19-22.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2017/V14/I32/19

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