Abstract：Objective To explore the clinical effect of different use of drugs under painless gastroscope in the treatment of acute non-variceal upper gastrointestinal bleeding. Methods A total of 92 patients with acute non-variceal upper gastrointestinal bleeding who were treated in Union Hospital of Tangshan City, Hebei Province from March 2019 to January 2020 were selected and randomly divided into groups, with 46 cases in each group. The spray group was treated with hemocoagulase under gastroscope, while the injection group was treated with adrenaline hydrochloride under gastroscope. The clinical efficacy, bleeding stop time, bleeding stop rate within five minutes, rebleeding rate within a week, serum lipopolysaccharide (LPS) content, serum C-reactive protein (CRP) content, and occurrence of adverse reactions were compared between the two groups. Results The efficacy of the injection group was significantly better than that of the spray group, and the difference was statistically significant (P ＜ 0.05). The bleeding stop time in the injection group was shorter than that in the spray group, and the difference was statistically significant (P ＜ 0.05). The bleeding stop rate within five minutes in the injection group was higher than that in the spray group, and the difference was statistically significant (P ＜ 0.05). The rebleeding rate within a week in the injection group was lower than that in the spray group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of serum LPS and CRP in the two groups were lower than those before treatment, while the serum levels of the injection group were lower than those of the spray group, and the differences were statistically significant (P ＜ 0.05). The incidence of adverse reactions in the injection group was lower than that in the spray group, and the difference was statistically significant (P ＜ 0.05). Conclusion The injection of adrenaline hydrochloride under painless gastroscopy has a better hemostatic effect than spraying hemocoagulase in the treatment of patients with acute non-varices upper gastrointestinal bleeding. It helps to reduce serum endotoxin and inflammatory factor content, thereby improving treatment safety.
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