Effect of Xuebijing Injection combined with conventional treatment on the quality of life and the protein expression of regulatory T cell in sepsis patients
CHEN Mingke ZHU Yong LI Na XIE Xiaohong
Intensive Care Unit, Hainan General Hospital, Hainan Province, Haikou 570311, China
Abstract：Objective To investigate the effect of Xuebijing Injection combined with conventional treatment on the quality of life and the protein expression of regulatory T cell (Treg) in sepsis patients. Methods A total of 120 patients with sepsis admitted to Hainan General Hospital from October 2013 to October 2016 were selected and divided into control group and treatment group according to random number table method, 58 cases in the control group were treated with conventional treatment, 62 cases in the treatment group were treated with conventional treatment combined with Xuebijing Injection intravenous injection. The quality of life, the level of serum Treg and the expression of Treg protein between the two groups after treatment were observed. Results After treatment, 12 cases′ quality of life improved, 25 cases were stable and 21 cases declined in the control group; 45 cases′ quality of life improved, 15 cases were stable and 2 cases declined in the treatment group; the difference between the two groups was statistically significant (P ＜ 0.05). Before treatment, the level of serum Treg and the expression protein of Treg between the two groups had no significant difference (P ＞ 0.05). After treatment, the level of serum Treg and the expression protein of Treg in the two groups were lower than those before treatment, and the indices in the treatment group were significant lower than those in the control group, the differences were statistically significant (P ＜ 0.05). The survival rate of the control group was remarkably lower than that of the treatment group, and the difference was significant (P ＜ 0.05). Conclusion Xuebijing Injection combined with conventional treatment can effectively improve the quality of life of patients with sepsis, and inhibit the expression of serum Treg protein, that may be one of its action mechanisms, so as to regulate the immune function.
陈明科 朱永 李娜 谢晓红. 血必净联合常规治疗对脓毒症患者生存质量及血清Treg蛋白表达的影响[J]. 中国医药导报, 2018, 15(26): 100-102,124.
CHEN Mingke ZHU Yong LI Na XIE Xiaohong. Effect of Xuebijing Injection combined with conventional treatment on the quality of life and the protein expression of regulatory T cell in sepsis patients. 中国医药导报, 2018, 15(26): 100-102,124.
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2018, Vol. 15 
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