The expression levels and clinical value of hypersensitive C-reactive protein, cystain C and interleukin 6-receptor in acute coronary syndrome
LI Feixing1 YI Mengyang2 TAN Junhui2 WANG Xiaoyuan1 WANG Rui1 LI Fangjiang1
1.Department of Cardiology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Graduate Faculty, Hebei North University, Hebei Province, Zhangjiakou 075000, China
Abstract：Objective To explore the clinical value of detecting the expressions of hypersensitive C-reactive protein (hs-CRP), cystain C and interleukin 6-receptor (IL-6R) for early identification of acute coronary syndrome in coronary heart disease patients. Methods A total of 265 patients undergoing coronary arteriography in the Department of Cardiology of the First Affiliated Hospital of Hebei North University from October 2016 to March 2017 were consecutively selected. According to the patients′ history, clinical manifestations and coronary angiographic results, all the patients were divided into acute myocardial infarction (AMI) group (89 cases), unstable angina pectoris (UAP) group (87 cases), stable angina pectoris (SAP) group (41 cases) and 48 patients without coronary stenosis as control group. The serum levels of hs-CRP and Cystatin C levels were measured with Hitachi 7070 automatic biochemical analyzer, and the level of IL-6R in peripheral blood was detected by enzyme-linked immunosorbent assay (ELISA). The expression levels of hs-CRP, Cystain C and IL-6R among the four groups were compared. Results The serum levels of hs-CRP, Cystatin C and IL-6R in the UAP group and AMI group were significantly higher than the control group (P ＜ 0.05)．The serum levels of hs-CRP, Cystatin C and IL-6R in the AMI group and UAP group were significantly higher than the SAP group (P ＜ 0.05). The serum levels of IL-6R, hs-CRP in the AMI group were higher than the UAP group (P ＜ 0.05), but Cystatin C level had no difference between the two groups (P ＞ 0.05). Conclusion The expression levels of hs-CRP, Cystatin C and IL-6R are significantly higher in AMI and UAP patients, which promotes that the three inflammatory factors may be involved in the pathophysiological processes of AMI and UAP. Therefore, clinical detection of hs-CRP, Cystatin C, IL-6R levels have certain reference value for the early diagnosis of acute coronary syndrome．
李飞星1 易梦阳2 谭俊辉2 王晓元1 王蕊1 李方江1. 血清超敏C反应蛋白、胱抑素C、白介素6-受体在急性冠脉综合征中的表达水平及临床价值[J]. 中国医药导报, 2018, 15(26): 34-37.
LI Feixing1 YI Mengyang2 TAN Junhui2 WANG Xiaoyuan1 WANG Rui1 LI Fangjiang1. The expression levels and clinical value of hypersensitive C-reactive protein, cystain C and interleukin 6-receptor in acute coronary syndrome. 中国医药导报, 2018, 15(26): 34-37.
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2018, Vol. 15 
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