Clinical study on the value of brain natriuretic peptide combination with Tei index for the cardiac function of patients with viral hepatitis cirrhosis
WANG Likun1 ZHANG Sumei2 WU Xueliang3 YANG Jielin4 YANG Ruimin1 HAN Chao1 WANG Yicheng1
1.Department of Ultrasound, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Department of Ultrasound, Xuanhua District Hospital in Zhangjiakou City, Hebei Province, Zhangjiakou 075000, China;
3.Vascular Surgery Department, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
4.Department of Gastroenterology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China
Abstract：Objective To investigate the value of brain natriuretic peptide (BNP) combination with Tei index in evaluating the cardiac function of patients with viral hepatitis cirrhosis. Methods Eighty patients with viral hepatitis cirrhosis treated in Department of Gastroenterology, the First Affiliated Hospital of Hebei North University from December 2014 to December 2016 were selected and divided into compensatory stage group (Child A group 30 cases) and non compensatory stage (Child B group 25 cases and Child C group 25 cases) according into Child-Pugh liver function grading standard. Another 20 healthy volunteers were selected as the healthy control group. The plasma BNP level was detected by ELISA method and Tei index was detected by colour doppler imaging. Results The plasma BNP level in the Child B and the Child C group was higher than that in the Child A group and the control group; the plasma BNP level in the Child C group was higher than that in the control group, and there was significant difference (P ＜ 0.05). The Tei index of left ventricle and IRT/ET value in the Child B and the Child C group were higher than those in the Child A group and the control group. The Tei index of left ventricle and IRT/ET value in the Child C group were higher than those in the control group, and there were also significant differences (P ＜ 0.05). While there was no difference in Tei index and IRT/ET value of right ventricle in all the groups (P ＞ 0.05). The plasma BNP and Tei index were consistent in assessing cardiac function in patients with viral hepatitis cirrhosis (r = 0.655, P ＜ 0.01). Multiple stepwise regression analysis showed that the Tei index of left ventricle was independent risk factor of plasma BNP (P ＜ 0.01). Conclusion The plasma BNP combination with Tei index could accurately assess the changes of cardiac function in patients with viral hepatitis cirrhosis and provide a scientific reference for clinical treatment and monitoring.
王立坤1 张素梅2 武雪亮3 杨婕琳4 杨瑞敏1 韩朝1 王义成1. 血浆钠尿肽联合Tei指数评估病毒性肝炎肝硬化患者心功能的临床研究[J]. 中国医药导报, 2018, 15(25): 127-131.
WANG Likun1 ZHANG Sumei2 WU Xueliang3 YANG Jielin4 YANG Ruimin1 HAN Chao1 WANG Yicheng1. Clinical study on the value of brain natriuretic peptide combination with Tei index for the cardiac function of patients with viral hepatitis cirrhosis. 中国医药导报, 2018, 15(25): 127-131.
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2018, Vol. 15 
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