Curative effect of combining therapy of Testosterone and Solifenacin for patients with lower urinary tract symptoms after transurethral resection of the prostate
CHEN Shenquan1 SU Jiuxiong2 LI Jianfei2 WU Baozhong1 LIU Mingjian1 YANG Dikuan1
1.Department of Urinary Surgery, the Second People's Hospital in Zhaoqing City, Guangdong Province, Zhaoqing 526060, China;
2.Department of Andrology, the Second People's Hospital in Zhaoqing City, Guangdong Province, Zhaoqing 526060, China
Abstract：Objective To investigate the clinical efficacy of Testosterone supplement combining with Solifenacin in the treatment for early stage of lower urinary tract symptoms (LUTS) after transurethral resection of the prostate (TUPP) for benign prostatic hyperplasia (BPH) patients. Methods Twenty-six cases with BPH treated in the Second People′s Hospital in Zhaoqing City from January 2017 to September 2017, that serum total testosterone (TT) was lower than normal range, and post TURP for 7 d with LUTS after removal of catheter were selected and they were randomly divided into experimental group and control group, with 13 cases in each group. The experimental group was applicated with Testosterone supplement and Solifenacin,and the control group was only supplemented with Testosterone supplement. The treatment course was 30 days. Prostate specific antigen (PSA), TT, International prostate symptom score-Quality of life (IPSS-QOL) score, overactive bladder symptom score (OABSS), the maximum flow rate (Qmax), residual urine (RU) and digital rectal examination between the two groups were compared before treatment, on 14th day and 30th day after treatment. Results Before treatment, the indices above between the two groups had no statistically significant differences (P ＞ 0.05). There was a statistically significant difference in the IPSS-QOL scores in the two groups before and 14th day after treatment (P ＜ 0.05). There were significant differences in TT, Qmax, IPSS-QOL and OABSS in the two groups before and in 30th day after treatment (P ＜ 0.05). On 14th day after treatment, there was no significant difference between the two groups in the indices above (P ＞ 0.05). On 30th day after treatment, the scores of IPSS-QOL and OABSS in the experimental group were all higher than those in the control group, the differences were statistically significant (P ＜ 0.05). On 14th and 30th day after treatment, both groups were not touched prostatic induration in rectal digital examination. Conclusion M receptor blocker combining with Testosterone supplemen can relieve the symptoms of LUTS after TURP effectively, and for BPH patients with low testosterone levels and LUTS can simultaneously treat with Testosterone supplement and M receptor blocker.
陈深泉1 苏玖雄2 黎鉴飞2 吴保忠1 刘明建1 杨帝宽1. 十一酸睾酮联合索利那新治疗经尿道前列腺电切术后早期出现下尿路症状的效果[J]. 中国医药导报, 2018, 15(24): 58-62.
CHEN Shenquan1 SU Jiuxiong2 LI Jianfei2 WU Baozhong1 LIU Mingjian1 YANG Dikuan1. Curative effect of combining therapy of Testosterone and Solifenacin for patients with lower urinary tract symptoms after transurethral resection of the prostate. 中国医药导报, 2018, 15(24): 58-62.
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2018, Vol. 15 
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