Abstract：Objective To study the toxicology of nanomagnetic beads and to understand the distribution of metabolism in rats. Methods Twenty-four healthy adult rats were randomly divided into 8 groups with 3 rats in each group. One group without any treatment as a blank control group, one group was injected with normal saline as positive control group, the other 6 groups were injected with nano-oxidized iron magnetic beads as the experimental group, the growth, behavior and neurological changes of the rats of each group were observed. HE staining and Prussian blue iron staining were used to observe the changes of organ structure and local pathological changes such as inflammatory reaction of rats in the experimental groups, and the distribution of magnetic beads in the main organs of the rats. Ten rats were randomly divided into two groups, and with 5 rats in each group, rats in the two groups were injected with ferromagnetic beads or normal saline respectively, and the cognitive function of rats was observed. Blood of 4 healthy New Zealand rabbits were collected after the injection of iron oxide magnetic beads and changes of related indexes were observed. Results There was no abnormal growth or appearance in the experimental group and the blank control group. The Longa score was 0, no abnormal changes were observed. Water maze experiments of the two groups including the escape latency and the number of crossing platforms were scored, there was no statistically significant (P > 0.05). There were no structural and pathological changes in the organ morphology of the rats in each group. The iron oxide magnetic beads had left the circulatory system and entered various organs of the rats after being injected for 5 minutes. Most of the magnetic beads were distributed in the spleen and liver. The difference in creatinine levels at different time points after injecting iron oxide magnetic beads in rabbits was statistically significant (P < 0.05), but still in the normal range. Other serum biochemical indicators, iron series indicators and blood routine indicators were not statistically significant (P > 0.05). Conclusion There is no obvious toxicological reaction by nanomagnetic beads. The toxicology related to nanomagnetic beads remain to be further explored.
王欣 张黎明. 纳米磁珠技术相关毒理实验研究[J]. 中国医药导报, 2018, 15(24): 9-13.
WANG Xin ZHANG Liming. Experimental study on toxicology related to nanomagnetic beads technology. 中国医药导报, 2018, 15(24): 9-13.
2018, Vol. 15 
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