Abstract：Objective To analyze the clinical effect of Paclitaxel combined with bronchial endoscopy intervention in the treatment of benign hypertrophic scar stenosis. Methods From May 2014 to May 2016, in Zhejiang Tumor Hospital, 40 patients with hypertrophic scar stenosis were selected, they were divided into Paclitaxel combined with bronchial endoscopy intervention treatment group (combined treatment group, 20 cases) and single bronchial endoscopy intervention treatment group (single treatment groups, 20 cases), sectional areas, shortness of breath, dyspnea index scores, pulmonary functions, clinical efficacy, incidences of adverse reactions of the two groups were statistically analyzed. Results compared with single group, in combined group, the airway diameter and cross-sectional area were significantly higher (P < 0.05), the dyspnea score was significantly lower (P < 0.05), the proportions of dyspnea grade 0, grade Ⅰwere significantly higher (P < 0.05), the proportions of dyspnea grade Ⅲ, grade Ⅳ were significantly lower (P < 0.05), the total treatment efficiency was significantly higher than the single treatment group (P < 0.05), the FEV1, VC, MVV, MMEF were significantly higher (P < 0.05). Conclusion The clinical effect of Paclitaxel combined with bronchial endoscopy intervention in the treatment of benign hypertrophic scar stenosis is better than single bronchial endoscopy intervention treatment.
[1] 王广发.良性中心气道狭窄的介入治疗[J].中华结核和呼吸杂志，2010，33（1）：14-16.
[2] 王利换，张杰，陈楠，等.局部应用紫杉醇抑制兔气管损伤后瘢痕组织形成的初步研究[J].中华结核和呼吸杂志，2013，36（3）：202-206.
[3] Latif F，Hennebry TA. Successful revascularization of re-stenosis of lower extremity arteries with localized delivery of paclitaxel [J]. Catheter Cardiovasc Interv，2008，72（2）：294-298.
[4] 李强.介入肺脏病学的临床应用现状与展望[J].中华结核和呼吸杂志，2008，31（1）：3 -5.
[5] 李亚强，李强，白冲，等.良性中央气道狭窄386 例病因分析及腔内介入治疗的疗效评价[J].中华结核和呼吸杂志，2008，31（5）：364-368.
[6] 林淑芳，丘新才，陈振华，等.球囊扩张术治疗结核性瘢痕型气道狭窄的疗效研究[J].中国医学装备，2015，12（4）：95-97.
[7] 邹杰，潘宁.丝裂霉素C治疗增生性瘢痕的研究现状[J].实用医院临床杂志，2010，7（4）：167 -170.
[8] 马艳莉，何元兵，齐曼古力·吾守尔，等.联合介入方法治疗良性瘢痕增生性气道狭窄的疗效分析[J].临床肺科杂志，2014，19（10）：1776-1779.
[9] 王洪武.金属支架置入治疗气道再狭窄及发生再狭窄的相关因素[J].中国组织工程研究与临床康复，2008，12（13）：2551-2555.
[10] 吴晓明，孙奎，张宏霞，等.丝裂霉素C影响增生性瘢痕成纤维细胞的凋亡[J].中国组织工程研究，2012，16（2）235-238.
[11] 崔嘉，张杰，王娟，等.局部应用丝裂霉素对良性瘢痕增生性气道狭窄抑制作用的初步研究[J].中华结核和呼吸杂志，2012，35（12）：901-906.
[12] Zhang J，Wang T，Wang J，et al. Effect of three interventional bronchoscopic methods on tracheal stenosis and the formation of granulation tissues in dogs [J]. Chin Med J （Engl），2010，123（5）：621-627.
[13] Anatoly S，Daniil S，Zufar H. Polyethylene pipeline bending stresses at an installation [J]. Am J Engineering Appl Sci，2016，9（2）：350-355.
[14] Leila KS ，Saman SK ，Seyed MIG，et al. Control-volume-based finite element modelling of liquefaction around a pipeline [J]. Geomat Nat Hazards Risk，2016，7 （4）：1287-1306.
[15] Mouhammad SA. The Compressed gas thermodynamics processes on gas pipelines [J]. Open J Fluid Dynam，2016， 6（1）：57-61.
[16] Khaled E ，Tieling Z ，Richard D. Maintaining pipeline integrity through holistic asset management [J]. Eur J Industr Engineering，2016，10（5）：618-638.
[17] Anonymous.PHMSA expands flow valves mandate for LDCs [J]. Pipeline Gas J，2016，243（12）：8.
[18] Tianying J，Luis F，Ayala HM. Thaddeus I.Network modelling and prediction of retrograde gas behaviour in natural gas pipeline systems [J]. Int J Engineering Syst Modelling Simulation，2016，8 （3）：169-182.
[19] Pavlo M，Olegas P，Roman B. Defectiveness of external and internal surfaces of the main oil and gas pipelines after long-term operation [J]. J Civ Engineering Management，2016，22（2）：279-286.
[20] Rafay I，Uzma R，Mark C. Fuel-switch decisions in the electric power industry under environmental regulations [J]. LIE Transactions，2016，48（3）：205-219.
[21] 王婷，张杰，王娟，等.紫杉醇对人胚肺成纤维细胞增殖的影响[J].中华结核和呼吸杂志，2010，33（1）：17-20.
2017, Vol. 14 
京公网安备 11010502046598号