Abstract：Objective To investigate the diagnosis value of serum laminin and hyaluronic acid in hepatic fibrosis. Methods From February 2015 to February 2017, in People's Hospital of Langfang City, 120 patients diagnosed with chronic hepatitis B were selected, amond them, mild hepatitis patients were 35 cases, moderate hepatitis patients were 30 cases, serious hepatitis patients were 25 cases, liver cirrhosis were 30 cases, and 30 healthy physical examinees were selected as normal control at the same time. The serum of patients and physical examinees were collected, laminin was tested by magnetism particulate, hyaluronic acid was tested by chemiluminiscence, liver tissue of patients were punctured for pathology examination, degree of fibrosis was determined, the relationship between the serum laminin and hyaluronic acid levels with the degree of liver fibrosis was analyzed. Results Laminin of mild hepatitis was compared with normal control, the difference was not statistically significant (P > 0.05). Laminin of moderate, serious hepatitis and liver cirrhosis patients showed gradually rising, that of liver cirrhosis patients was the highest, it was (190.77±38.65) ng/L, and these were higher than that of normal control, the differences were statistically significant (P < 0.05). Serum hyaluronic acid levels of chronic hepatitis patients were higher than that of normal contol, the difference was statistically significant (P < 0.05), serum hyaluronic acid levels of mild, moderate, serious hepatitis and liver cirrhosis patients showed gradually rising, the differences were statistically significant (P < 0.05). The serum hyaluronic acid levels of liver cirrhosis S1, S1, S3, S4 stage showed gradually rising, and these were compared with S0 stage, the differences were statistically significant (P < 0.05). Conclusion Serum laminin and hyaluronic acid can reflect the degree of liver fibrosis, with diagnostic value.
2017, Vol. 14 
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