Observation of short-term efficacy, toxic side effects and survival situation of TACE combined with Tegafur Gimeracil Oteracil Potassium in treatment of primary hepatic carcinoma
QIN Wenban LI Yongbiao TANG Chaoli LU Wenxi ZHOU Cui
Department of Oncology, Chongzuo People's Hospital, Guangxi Zhuang Autonomous Region, Chongzuo 532200, China
Abstract：Objective To study the influence of short-term efficacy, toxic side effects and survival time of TACE combined with oral Tegafur Gimeracil Oteracil Potassium on treatment of primary hepatic carcinoma. Methods From February 2013 to January 2014, in Chongzuo People's Hospital, 50 patients with primary hepatic carcinoma admitted into the hospital were divided into two groups by random number table, with 25 cases in each group. Simple treatment group was given TACE, and association group was given Tegafur Gimeracil Oteracil Potassium on the basis of treatment of simple treatment group. Patients of two groups were given follow-up investigation, and short-term efficacy, toxic side effects, survival situation within 3 years and survival quality of two groups were compared. Results The short-term effective rate, survival rate of 1, 2, 3 years and survival time of association group were 84.00%, 84.00%, 68.00%, 44.00%, (17.63±1.85) months, which were significantly higher than 56.00%, 52.00%, 32.00%, 16.00%, (10.52±1.74) months of simple treatment group (P < 0.05 or P < 0.01); the total incidence of toxic side effects in association group was 4.00%, which was significantly lower than 40.00% in simple treatment group, and there was statistical difference (P < 0.01); the scores of each survival quality of association group were significantly higher than those of simple treatment group, and there were statistical difference (P < 0.01). Conclusion TACE combined with oral Tegafur Gimeracil Oteracil Potassium in treatment of patients with primary hepatic carcinoma can significantly increase short-term efficacy, reduce toxic side effects, lengthen survival time and improve survival quality, which is worthy of further promotion.
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2017, Vol. 14 
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