超声及微泡介导干细胞治疗心肌梗死的研究进展

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摘要利用干细胞修复梗死心肌的方法极具潜力，但单纯外源性移植存在免疫排斥、病原体传播、储存、包装等问题，更重要的是，干细胞无法高效归巢到靶区。而超声靶向微泡破坏技术凭借其非侵入性、低免疫原性、可重复性、靶向性等优点成为一种新型基因传递体系，在干细胞趋化和基因治疗的研究中被广泛应用。本文就超声及微泡辅助干细胞治疗心肌梗死的方法进行综述。

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	张杰穆玉明

关键词 ：超声, 微泡, 干细胞治疗, 心肌梗死

Abstract：The method of using stem cells to repair infarcted myocardium has great potential. But there are a series of questions with simple exogenous transplantation, such as immunological rejection, transmission of pathogens, storage, packing and more, the stem cells can′t home to the targeted area efficiently. As a novel gene delivery system, ultrasound-targeted microbubble destruction has been widely used for recruiting stem cells and gene therapy for its advantages of noninvasiveness, low immunogenicity, repeatability, spatial target specificity, etc. This article reviewes the methods of ultrasound and microbubble mediated stem cell in the treatment of myocardial infarction.

Key words： Ultrasound Microbubble Stem cell therapy Myocardial infarction

基金资助:国家自然科学基金资助项目（81460266）；
新疆重大疾病医学重点实验室开放课题项目（SKLIB-XJMDR-2014-13）。

通讯作者: 穆玉明（1963.1-），男，博士，主任医师，教授，博士生导师，新疆医科大学第一附属医院心脏超声诊断科主任；研究方向：超声辅助基因转染心肌梗死的治疗及心肌的三维应变。

作者简介: 张杰（1992.9-），女，新疆医科大学研究生学院2015级影像医学与核医学专业在读硕士研究生；研究方向：超声辅助基因转染心肌梗死的治疗。

引用本文:

张杰穆玉明. 超声及微泡介导干细胞治疗心肌梗死的研究进展[J]. 中国医药导报, 2017, 14(23): 29-32.
ZHANG Jie MU Yuming. Research progress of ultrasound and microbubble mediated stem cell in the treatment of myocardial infarction. 中国医药导报, 2017, 14(23): 29-32.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2017/V14/I23/29

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