Effect, relevant clinical indicators and prognosis analysis of Low Molecular Heparin combined with Prednisone in the treatment of children with nephrotic syndrome
TIAN Jianmei1 LIU Xiaowei2
1.Department of Paediatric, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010059, China;
2.Department of Nursing, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010059, China
Abstract：Objective To analyze the clinical effects, relevant indicators and prognosis of Low Molecular Heparin Combined with Prednisone in the treatment of children with nephrotic syndrome. Methods Clinical data of 84 children confirmed to be with nephrotic syndrome in Affiliated Hospital of Inner Mongolia Medical University were analyzed from January 2016 to January 2017, and they were divided into two groups according to different treatment methods applied: 42 cases were given only Low Molecular Heparin for treatment as control group, while the other 42 children were treated with Low Molecular Heparin combined with Prednisone as observation group. The clinical indicators including coagulation indicators, total cholesterol, plasma albumin and 24-h proteinuria, renal function after prognosis, and life quality were compared between two groups for one month after treatment. Results The time for activation of partial thromboplastin and prothrombin, incidence rate of adverse reactions between two groups were compared, with no statistical differences (P > 0.05). After treatment, serum total cholesterol and 24-h proteinuria levels of observation group were both lower than those of control group, and plasma albumin of observation group was higher than that of control group, the differences were statistically significant (P < 0.01). After treatment, the creatinine clearance rate and quality of life scores in observation group were higher than those in control group, urea nitrogen, serum creatinine in observation group were lower than those in control group, the differences were statistically significant (P < 0.01). Conclusion Children with nephrotic syndrome are treated with Low Molecular Heparin combined with Prednisone, these treatment will improve the curative effect, and reduce adverse reaction, but also promote the prognosis effect. Therefore, this therapy is significant value to be popularized in clinical application and for research.
田建梅1 刘晓伟2. 低分子肝素联合泼尼松治疗小儿肾病综合征的效果、相关临床指标及预后分析[J]. 中国医药导报, 2017, 14(24): 147-150.
TIAN Jianmei1 LIU Xiaowei2. Effect, relevant clinical indicators and prognosis analysis of Low Molecular Heparin combined with Prednisone in the treatment of children with nephrotic syndrome. 中国医药导报, 2017, 14(24): 147-150.
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2017, Vol. 14 
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