Advance of connexin 43 and connexin 43-formed channels in the spinal cord injury
ZHANG Shuangshuang HU Ji▲ HUANG Jinxiu XIE Lijie LIU Jiao
Department of Anesthesiology, Liyuan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Hubei Province, Wuhan 430077, China
Abstract：Connexin 43 are integral membrane proteins which span the plasma membrane four times, and widely distributed in the central nervous system. Connexin 43 can form hemi channels and gap junctions which provides a direct cytoplasmic pathway between contacting cells. In the spinal cord injury, the levels of connexin 43 mRNA and protein obviously up-regulated. Also, the permeability of the hemichannels and gap junctions increased, which form a well-known pathway for the release of intracellularmetabolites and the entry of extracellularsubstances, that can play major roles in the secondary injury by the way of aggravating the inflammatory response, disruption of blood-spinal cord barrier, and neuronal death. In addition, the blockers of connexin 43 channels and other methods which regulate the expression of connexin 43 and the permeability of connexin 43 channels can act obvious protective effects in the spinal cord injury. This review discusses the latent injury mechanisms induced by connexin 43 and connexin 43 channels in the spinal cord injury, and relevant treatments on the basis of it.
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2017, Vol. 14 
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