Effect of Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets on bone mineral density, estradiol and immune function in postmenopausal osteoporosis patients with deficiency of liver and kidney
JIANG Qian1 HUANG Jianhua2 ZHENG Jun3 LIU Yingjie1
1.TCM Pharmacy, Rui′an Hospital of Traditional Chinese Medicine, Zhejiang Province, Rui′an 325200, China;
2.Department of Traditional Chinese Medicine and Traumatology, Rui′an People′s Hospital, Zhejiang Province, Rui′an 325200, China;
3.Department of Radiology, Rui′an People′s Hospital, Zhejiang Province, Rui′an 325200, China
Abstract：Objective To investigate the effect of Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets on bone mineral density, estradiol and immune function in postmenopausal osteoporosis (PMO) patients with deficiency of liver and kidney. Methods Two hundred PMO patients with deficiency of liver and kidney in Rui′an Hospital of Traditional Chinese Medicine from October 2014 to April 2016 were selected, and they were divided into control group and treatment group by random number table, with 100 cases in each group. The control group was given Alendronate Sodium and Vitamin D3 Tablets combined with Gukang Capsules, while the treatment group was treated with Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets. The bone mineral density, estradiol and immune function were compared between the two groups. Results Compared with before treatment, the bone mineral density of lumbar 1- lumbar 4 (L1-L4) and femoral neck (FN), serum estradiol, IgG and IgM in two groups increased (P ＜ 0.05). After treatment, the bone mineral density of L1-L4 and FN, serum estradiol, IgG and IgM in treatment group were higher than those in control group (P ＜ 0.05). There was no statistically significant difference in the IgA level between the two groups (P ＞ 0.05). Conclusion Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets in treatment of PMO patients with deficiency of liver and kidney can effectively improve immune function, regulate hormone levels and increase bone mineral density.
姜茜1 黄建华2 郑军3 刘英杰1. 加味知柏地黄丸合阿仑膦酸钠维D3片对绝经后骨质疏松症肝肾不足证患者骨密度、血清雌二醇和免疫功能的影响[J]. 中国医药导报, 2018, 15(23): 117-120.
JIANG Qian1 HUANG Jianhua2 ZHENG Jun3 LIU Yingjie1. Effect of Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets on bone mineral density, estradiol and immune function in postmenopausal osteoporosis patients with deficiency of liver and kidney. 中国医药导报, 2018, 15(23): 117-120.
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2018, Vol. 15 
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