Abstract：Objective To detect the amount of Malassezia in the skin of patients with atopic dermatitis (AD), and explore its correlation with the disease severity. Methods 20 mild, 20 moderate and 20 severe AD patients were selected from the First Affiliated Hospital of Chengdu Medical College from April to September 2017. Skin scales were collected as samples from the lesion and non lesion areas on the face and upper limb of AD patients as well as the corresponding areas of 20 healthy control subjects. The density of Malassezia was recorded at high magnification by fluorescent staining method. Then the correlation between the density of Malassezia and the disease severity was analyzed. Results The density of Malassezia in the lesion and non lesion areas on the face of the mild, moderate and severe AD patients was significantly higher than those of the upper limbs (P ＜ 0.05). The density of Malassezia in each skin area of mild, moderate and severe AD patients was significantly higher than that of healthy control subjects (P ＜ 0.05). The density of Malassezia in each skin area of AD patients was not correlated with the disease severity (P ＞ 0.05). Conclusion The amount of Malassezia in the skin of AD patients is related to the site, but not to the disease severity.
吴红梅 陆茂 欧美 罗媛元. 特应性皮炎患者皮肤马拉色菌菌量及其与病情严重程度相关性研究[J]. 中国医药导报, 2018, 15(23): 96-99.
WU Hongmei LU Mao OU Mei LUO Yuanyuan. Study on the amount of Malassezia in the skin of patients with atopic dermatitis and its correlation with the disease severity. 中国医药导报, 2018, 15(23): 96-99.
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2018, Vol. 15 
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