The effect of thunder-fire moxibustion in the treatment of chronic fatigue syndrome and its influence on T lymphocyte subsets in peripheral blood
LUO Haili1 CHEN Shumin2 YU Ximei1 LI Ying1 CHEN Xiuhua1 WANG Cong1
1.Center of Traditional Remedies, the Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510120, China;
2.Department of Physical Therapy, Guangdong Cadre Sanatorium, Guangdong Province, Guangzhou 510970, China
Abstract：Objective To evaluate the efficacy and safety of thunder-fire moxibustion in the treatment of chronic fatigue syndrome (CFS) on Shenque acupoint (CV8) comparing with common moxa-stick moxibustion therapy, and to investigate its influence on CD3+, CD4+, CD8+ T lymphocyte subsets in peripheral blood. Methods From October 2016 to June 2017, 85 cases of patients diagnosed as CFS in Center of Traditional Remedies, the Second Clinical Medical College, Guangzhou University of Chinese Medicine were selected as research objects and divided into the experimental group and the control group. The experimental group was treated with thunder-fire moxibustoin, while the control group was treated with common moxa-stick moxibustion. Both groups chose CV8, once every other day, three times were as one course, for 4 courses. Finally, 38 cases in the experimental group and 37 cases in the control group finished the study. The changes of CFS clinical syndrome scale and the levels of T lymphocyte subsets (CD3+, CD4+, CD8+) in peripheral blood before and after treatment were observed. Results Both groups could decrease the scores of clinical syndrome scale, and the experimental group was better than that of the control group, the difference was statistically significant (P ＜ 0.05). Both groups could increase the number of CD3+, and the effective rate in the experimental group and control group was 65.79%, 43.24% respectively, the difference was statistically significant (P ＜ 0.05). Both groups could two-way regulate the ratio of CD4+/CD8+, and the effective rate in the experimental group and control group was 50.00%, 21.62% respectively, the difference was statistically significant (P ＜ 0.05). There were no obvious adverse events in both groups. Conclusion Both thunder-fire moxibustion and common moxa-stick moxibustion can effectively improve the clinical symptoms of CFS, increase the number of CD3+ and restore the balance of CD4+/CD8+ ratio, but the effect of thunder-fire moxibustion is better. Both are safe, easy to operate, and valuable for clinical application.
罗海丽1 陈淑敏2 余细妹1 李颖1 陈秀华1 王聪1. 雷火灸治疗慢性疲劳综合征的效果及对外周血T淋巴细胞亚群的影响[J]. 中国医药导报, 2018, 15(22): 107-111.
LUO Haili1 CHEN Shumin2 YU Ximei1 LI Ying1 CHEN Xiuhua1 WANG Cong1. The effect of thunder-fire moxibustion in the treatment of chronic fatigue syndrome and its influence on T lymphocyte subsets in peripheral blood. 中国医药导报, 2018, 15(22): 107-111.
[1] Holmes GP，Kaplan JE，Gantz NM，et al. Chronic Fatigue Syndrome：a Working Case Definition [J]. Ann Intern Med，1988，108（3）：387-389.
[2] Fukuda K，Straus SE，Hickie I. The Chronic Fatigue Syndrome：a Comprehensive Approach to Its Definition and Study.International Chronic Fatigue Syndrome Study Group [J]. Ann Intern Med，1994，121（12）：953-959.
[3] Maes M，Bosmans E，Kubera M. Increased expression of activation antigens on CD8+ T lymphocytes in Myalgic Encephalomyelitis/chronic fatigue syndrome：inverse associations with lowered CD19+ expression and CD4+/CD8+ ratio，but no associations with（auto）immune，leaky gut，oxidative and nitrosative stress biomarkers [J]. Neuro Endocrinol Lett，2015，36（5）：439-446.
[4] Curriu M，Carrillo J，Massanella M，et al. Screening NK-，B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome [J]. J Transl Med，2013， 11：68.
[5] 郭爱松，顾一煌，金宏柱.艾灸治疗慢性疲劳综合征的疗效对照研究[J].辽宁中医药大学学报，2007，9（4）：29-30.
[6] 饶晓明，罗昭娜，王秀玲.热敏灸治疗慢性疲劳综合征33例[J].江西中医药，2011，42（5）：66-67.
[7] 林玉敏.艾灸对慢性疲劳模型大鼠的免疫干预及临床研究[D].广州：广州中医药大学，2014.
[8] 田亮，王金海，雒成林，等.膏肓灸法治疗慢性疲劳综合征：随机对照研究[J].中国针灸，2015，35（11）：1127-1130. DOI：10.13703/j.0255-2930.2015.11.014
[9] 邹佑云.艾灸神阙穴治疗慢性疲劳综合征随机对照临床研究[J].宜春学院学报，2011，33（8）：94，166
[10] 诸毅晖，成词松，钟兰.神阙透皮药贴治疗慢性疲劳综合征的随机对照研究[J].成都中医药大学学报，2010， 33（1）：25-26.
[11] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：30.
[12] Kavelaars A，Kuis W，Knook L，et al. Disturbed neuroendcrine-immune interactions in chronic fatigue syndrome [J]. J Clin Endocrinol Metab，2000，85（2）：692-696.
[13] Shephard IU. Chronic fatigue syndrome.A brief review of functional disturbances and potential therapy [J]. J Sports Med Phys Fitness，2005，45（3）：381-392.
[14] Collatz A，Johnston SC，Staines DR. A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis [J]. Clin Ther，2016，38（6）：1263-1271.
[15] Kobayashi K. Induction of heat-shock protein（hsp）by moxibustion [J]. Am J Chin Med，1995，23（3/4）：327-330.
[16] Chang XR，Peng L，Yi SX，et al. Association of high expression in rat gastric mucosal heat shock protein 70 induced by moxibustion pretreatment with protection against stress injury [J]. World J Gastroenterol，2007，13（32）：4355-4359.
[17] 吴焕淦，马晓芃，周次利，等.灸法研究现状与战略思考[J].世界中医药，2013，8（8）：845-851.
[18] 赵时碧.雷火灸疗法[M].北京：人民卫生出版社，2014：238-241.
[19] 兰彩虹，冯玲媚.雷火灸五脏俞治疗慢性疲劳综合征疗效观察[J].中国中医药咨讯，2011，2（31）：160.
[20] 左振芹.雷火灸五脏背俞穴为主治疗慢性疲劳综合征的临床研究[D].贵阳：贵阳中医学院，2014.
[21] 肖金良，杨孝芳，施杨婉琳，等.神阙灸治病机理初探[J].江苏中医药，2010，42（6）：3-4.
[22] 高树中.中医脐疗大全[M].济南：济南出版社，2009：8-10.
[23] 赵娜，谢晨，陈云飞.不同配比药物艾条温和灸治疗风寒湿证神经根型颈椎病400例临床观察[J].中医杂志，2017，58（12）：1024-1027.
[24] 吴璐一，杨玲，周次利，等.艾灸温度影响因素及与疗效关系研究进展[J].环球中医药，2013，6（4）：309-313.
[25] 朱兵.系统针灸学——复兴“体表医学”[M].北京：人民卫生出版社，2015：163-168.
[26] 王凤玲，李蕙，魏正岫，等.灸神阙穴对中老年人免疫功能及其全身状态的影响[J].中国针灸，1996，16（7）：389-390.
[27] Yamashita H，Ichiman Y，Tanno Y. Changes in peripheral lymphocyte subpopulations after direct moxibustion [J]. Am J Chin Med，2001，29（2）：227-235.
2018, Vol. 15 
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