唾液幽门螺杆菌检测在胃癌发生发展中的价值

摘要
图/表
参考文献(19)
相关文章 (9)

全文: PDF (667 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的研究唾液幽门螺杆菌（Hp）与胃癌发展各阶段的相关性。方法选取2016年1月~2017年10月首都医科大学附属北京潞河医院201例病理诊断为浅表性胃炎、萎缩性胃炎、不典型增生及胃癌的患者唾液，应用幽门螺杆菌唾液检测板（HPS）检测法对唾液Hp进行检测，同时根据年龄、性别、牙周状况及胃内不同病变分组，分析口腔Hp感染率及其相关性。结果纳入试验的患者中，男性Hp感染率（75.5%）高于女性（54.5%），差异有统计学意义（P < 0.05）；青年组Hp感染率为42.9%，中年组为69.9%，老年组为75.4%，三组间比较差异有统计学意义（P < 0.05）；萎缩性胃炎组、不典型增生组、胃癌组口腔Hp感染率分别为64.5%、76.0%、75.0%，明显高于浅表性胃炎组（44.4%），差异均有统计学意义（P < 0.05）；牙龈炎组、牙周炎组患者的口腔Hp感染率与牙周健康组比较明显增高，差异均有统计学意义（P ＜ 0.05）；牙周炎组与牙龈炎组Hp感染率比较明显增高，差异有统计学意义（P ＜ 0.05）。结论幽门螺杆菌在口腔中存在高感染率现象，口腔幽门螺杆菌感染率与年龄、性别因素及牙周炎有关。口腔Hp感染率与胃癌前病变和胃癌的病变有关，可能是胃癌前病变和胃癌的重要危险因素。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	罗伟1 朱志超1 徐宝宏1▲ 罗振华2

关键词 ：幽门螺杆菌, 唾液, 胃癌前病变, 胃癌, 牙周炎

Abstract：Objective To investigate the correlation between salivary Helicobacter pylori (Hp) and various stages of gastric cancer development. Methods Saliva was collected from 201 patients with pathologically diagnosed superficial gastritis, atrophic gastritis, dysplasia, and gastric cancer in Beijing Luhe Hospital, Capital Medical University from January 2016 to October 2017. The HPS test was used to detect Hp in saliva. The incidence and correlation of Hp infection were analyzed according to age, sex, periodontal status, and different gastric lesions. Results Among all patients included in the trial, the male infection rate (75.5%) was higher than that of female (54.5%) (P < 0.05). The Hp infection rates of middle-aged and elderly patients were 69.9% and 75.4% respectively, which were significantly different from the younger ones (42.9%) (P < 0.05). The positive rates of oral Hp in the atrophic gastritis group, atypical hyperplasia group, and gastric cancer group were 64.5%, 76.0%, and 75.0%, respectively, which were significantly higher than superficial gastritis group (44.4%), and the differences were statistically significant (P < 0.05). The infection rates of gingivitis group and periodontitis group were higher than periodontal health group, and the differences were statistically significant (P < 0.05). Conclusion Oral Hp infection rate is higher in the oral cavity, and related to age, gender and periodontal disease. The oral Hp infection rate is related to the precancerous lesions and gastric cancer. The presence of oral Hp may be an important risk factor for gastric precancerous lesions and gastric cancer.

Key words： Helicobacter pylori Saliva Gastric precancerous lesions Gastric cancer Periodontitis

通讯作者: ▲通讯作者

引用本文:

罗伟1 朱志超1 徐宝宏1▲ 罗振华2. 唾液幽门螺杆菌检测在胃癌发生发展中的价值[J]. 中国医药导报, 2018, 15(22): 88-91.
LUO Wei1 ZHU Zhichao1 XU Baohong1▲ LUO Zhenhua2. The value of the Helicobacter pylori in saliva in the occurrence and development of gastric cancer. 中国医药导报, 2018, 15(22): 88-91.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I22/88

[1] Sugano K，Tack J，Kuipers EJ，et al. Kyoto global consensus report on Helicobacter pylori gastritis [J]. Gut，2015， 64（9）：1353-1367.
[2] Graham DY. Helicobacter pylori update： gastric cancer， reliable therapy， and possible benefits [J]. Gastroenterology，2015，148（4）：719-731.
[3] Krajden S，Fuksa M，Anderson J，et al. Examination of human stomach biopsies， saliva， and dental plaque for campylobacter-pylori [J]. J Clin Microbiol，1989，27（6）：1397-1398.
[4] Zou QH，Li RQ. Helicobacter pylori in the oral cavity and gastric mucosa：a meta-analysis [J]. J Oral Pathol Med，2011，40（4）：317-324．
[5] Lukes P，Pavlík E，Potuzníkova B，et al. Comparison of Helicobacter pylori genotypes obtained from the oropharynx and stomach of the same individuals-a pilot study [J]. Prague Med Rep，2012，113（3）：231-239.
[6] Silva DG，Stevens RH，Macedo JM，et al. Presence of Helicobacter pylori in supragingival dental plaque of individuals with periodontal disease and upper gastric diseases [J]. Arch Oral Biol，2010，55（11）：896-901.
[7] Pay?觔o SLM，Rasmussen LT. Helicobacter pylori and its reservoirs： A correlation with the gastric infection [J]. World J Gastrointest Pharmacol Ther，2016，7（1）：126.
[8] 中华医学会消化病学分会，房静远，刘文忠，等.中国慢性胃炎共识意见（2012年，上海）[J].中华消化杂志，2013， 33（1）：5-16.
[9] Jky H，Lai WY，Ng WK，et al. Global Prevalence of Helicobacter pylori Infection： Systematic Review and Meta-Analysis [J]. Gastroenterology，2017，153（2）：420-429.
[10] Lu B，Li M. Helicobacter pylori eradication for preventing gastric cancer [J]. World J Gastroenterol，2014，20（19）：5660-5665.
[11] 叶国钦，Karin，Everett，等.口腔幽门螺杆菌感染与胃幽门螺杆菌感染的相关性探讨[J].中华消化杂志，2011， 31（7）：470-473.
[12] Bharath TS，Reddy MS，Dhanapal R，et al. Molecular detection and corelation of Helicobacter pylori in dental plaque and gastric biopsies of dyspeptic patients [J]. J Oral Maxillofac Pathol，2014，18（1）：19-24.
[13] Momtaz H，Souod N，Dabiri H，et al. Study of Helicobacter pylori genotype status in saliva， dental plaques， stool and gastric biopsy samples [J]. World J Gastroenterol，2012，18（17）：2105-2111.
[14] Song Q，Lange T，Spahr A，et al. Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR [J]. J Med Microbiol，2000，49（4）：349-353.
[15] Yee KC，Wei MH，Yee HC，et al. A screening trial of Helicobacter pylori specific antigens tests in saliva to identify an oral infection [J]. J Digestion，2013，87（4）：163-169.
[16] Song HY，Li Y. Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori? [J]. World J Gastroenterol，2013，19（39）：6645-6650.
[17] 高文，胡伏莲，王晓敏.含呋喃唑酮的四联疗法联合口腔洁治对幽门螺杆菌根除多次失败的补救治疗[J].中华医学杂志，2011，91（12）：836-839.
[18] 贾春玲，姜广水，杨学馨，等.2种牙菌斑控制法对胃黏膜幽门螺杆菌再感染的影组响研究[J].华西口腔医学杂志，2009，27（2）：172-174.
[19] Wang XM，Yee KC，Hazekitaylor N，et al. Oral Helicobacter pylori， its relationship to successful eradication of gastric H. pylori and saliva culture confirmation [J]. J Physiol Pharmacol，2014，65（4）：559-566.