光基因技术调控星形胶质细胞释放ATP和谷氨酸及其对阿尔茨海默病神经元保护机制的研究展望

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摘要阿尔茨海默病是中枢神经系统退行性病变之一，其病理机制主要是各种原因导致的神经元Aβ沉积，包括ATP和谷氨酸不足引起的Aβ沉积。应用光基因技术可以选择性激活表达光敏感通道蛋白的星形胶质细胞，并促其释放ATP和谷氨酸，从而阻断由于ATP和谷氨酸不足引起的Aβ沉积。因此光基因技术有望应用于阿尔茨海默病的治疗，并且避免药物治疗在非选择性及广泛不良反应方面的缺点。

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	柳浦青何冰冰陈锋

关键词 ：阿尔茨海默病, 光基因技术, 光敏感通道, 三磷酸腺苷, 谷氨酸

Abstract：Alzheimer disease′s (AD) is one kind of degenereratly neuropathic disease. The pathomechanism of AD is the deposite of Aβ peptide, including ATP and glutamate insufficiency resulted Aβ deposite. Application of phogenetic technology can selectively activate astrocytes transfected with ChR2, promote the release ATP and glutamate, block the Aβ aggregation producing by insufficient of ATP and glutamate. Conclusion as a result, ChR2 mediated optogenetic technology can be used for AD treatment. This new treropeutical method will avoid the defects of non-selective and extensive side-effects.

Key words： Alzheimer′s disease Optogenetic technology ChR2 ATP Glutamate

通讯作者: 陈锋（1963.2-），女，主任药师；研究方向：临床药学。

作者简介: 柳浦青（1985.3-），女，硕士；研究方向：神经病理分子机制与神经药理学。

引用本文:

柳浦青何冰冰陈锋. 光基因技术调控星形胶质细胞释放ATP和谷氨酸及其对阿尔茨海默病神经元保护机制的研究展望[J]. 中国医药导报, 2017, 14(31): 40-43.
LIU Puqing HE Bingbing CHEN Feng. The research progress in mechanism of optogenetics activated astrocytes release ATP and glutamate to protect neurons in Alzheimer′s disease. 中国医药导报, 2017, 14(31): 40-43.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2017/V14/I31/40

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