Abstract：Objective To investigate the specific repairing effects of flavonoids extract from Pteris multifida Poir on photoaged skin of mice caused by ultraviolet irradiation, and to provide a theoretical basis for the medicinal use of this plant. Methods Forty damaged model mice with photoaging caused by ultraviolet irradiation were selected, according to the gender, they were divided into group A (no treatment), group B (smeared normal saline), group C (smeared normal saline + vitamin C), group D (smeared normal saline + flavonoids rutin extract), with 10 mice in each group. Follow-up observation of 10 days, the differences of surface evaluation of roughness (SER), surface evaluation of scales (SESC), surface evaluation of wrinkles (SEW), percentage of healed area, microvessel density (MVD), skin healing time, scab time and fluff generated time among the four groups were compared. Results In the 7th and 10th days, the SER, SESC, and SEW in group A, B, and C were all significantly higher than those of group D (all P ＜ 0.05), the percentage of healed area and MVD were significantly lower than those of group D (all P ＜ 0.05). The skin healing time, scab time and fluff generated time in group A, B, C were significantly shorter than those of group D (all P ＜ 0.05), and the results of each index in group A were maximum, and the results of each index in group D were minimum. Skin histopathologic examination showed that, the skin collagen fibre in group A showed no regular fracture, the emptiness of the dermis in group B was enlarged gradually, the epidermis of group C was relatively intact, the epidermis of group D had better recovery conditions and collagen fibers were also more than other groups. Conclusion Biological flavonoids rutin substances contribute to the repair of photoaged skin, reflected in the skin appearance and internal organizational structure, the efficacy is better than vitamin C, which can greatly enhance the skin healing time.
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2017, Vol. 14 
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