Analysis of related factors of Vancomycin concentration not up to standard in ICU
YIN Yanyan1 ZHU Jing2 JIANG Li3▲
1.Urinary and Metabolic Center, Beijing Rehabilitation Hospital of Capital Medical University, Beijing 100144, China;
2.Department of Pneumology, Fu Xing Hospital, Capital Medical University, Beijing 100038, China;
3.Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, Beijing 100038, China
Abstract：Objective To investigate the influencing factors of Vancomycin concentration not up to standard, optimize clinical use. Methods From January 2016 to December 2017, in Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, the patients who received monitoring of Vancomycin blood concentration, and got creatinine clearance rate examination, hemodynamic monitoring at same time were retrospectivlye analyzed, the patients with drug dose up to standard were selected, according to Vancomycin concentration wheather up to standard or not, they were divided into two groups, blood concentration 10-20 μg/mL was as up to standard group, blood concentration 0～<10 μg/mL as not up to standard group. The basic information, plasma albumin, alanine aminotransferase, creatinine clearance rate (CCr), body mass index (BMI), and liquid balance during using Vancomycin were collected, single factor analysis and Logistic regression analysis were used to find out the factors influencing the serum concentration of Vancomycin. Results There were 55 patients with drug dose up to standard and whole clinical data, 28 cases were in blood concentration up to standard group, 27 cases were in blood concentration not up to standard group, BMI, CCr, CO, liquid balance in two groups were compared, the differences were statistically significant (P < 0.05), Logistic regression analysis result showed that CO, liquid balance during using Vancomycin were influence factors of blood concentration not blood concentration of patients in ICU (P < 0.05). Conclusion The level of CO, liquid balance during using Vancomycin are the factors influencing the serum concentration of vancomyc influence factors of blood concentration not blood concentration of patients in ICU.
尹燕燕1 朱婧2 姜利3▲. ICU患者万古霉素血药浓度不达标的相关因素分析[J]. 中国医药导报, 2018, 15(21): 110-113.
YIN Yanyan1 ZHU Jing2 JIANG Li3▲. Analysis of related factors of Vancomycin concentration not up to standard in ICU. 中国医药导报, 2018, 15(21): 110-113.
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2018, Vol. 15 
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