Application effect of Sarpogrelate combined with Clopidogrel in patients after carotid artery stenting
ZHANG Yaoyuan1 WU Xueliang2 ZOU Yu′an1
1.Department of Neurology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Department of Vascular Surgery, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China
Abstract：Objective To discuss the clinical effectiveness and safety of Sarpogrelate combined with Clopidogrel in carotid artery stenting (CAS). Methods The clinical follow-up data of 55 cases with carotid artery stenosis treated by carotid artery stenting were retrospectively collected from January 2012 to January 2015 in the Department of Neurology and Vsculr Surgery in the First Affiliated Hospital of Hebei North University. According to treatment method, all patients were divided into Sarpogrelate combined with Clopidogrel group (observation group, 28 cases) and Aspirin combined with Clopidogrel (control group, 27 cases). Postoperative new stroke, restenosis, bleeding and mortality were compared between two groups. Results There was no significant difference with new stroke and restenosis between two groups (P > 0.05). The incidence of bleeding events in the observation group was lower than that in the control group (P < 0.05). There was no death between two groups (P > 0.05). Conclusion Sarpogrelate combined with Clopidogrel compared with Aspirin combined with Clopidogrel for antiplatelet therapy after CAS has no differences in new stroke and restenosis. Sarpogrelate is more safer and effective than Aspirin.
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2018, Vol. 15 
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