Abstract:Objective To understand the status of knowledge, attitude and demands of birth defect prevention among the responds in Jiangsu Province in order to provide the bases for the service modes of primary prevention work of birth defect. Methods A survey was made among the responds from Zhenjiang, Taixing, Suining and Lianyungang from November 2016 to June 2017, and the contents of questionnaire contained personal characteristics, the knowledge of birth defect prevention and sources of knowledge. Results A total of 2143 questionnaires were collected and the valid questionnaires were 2057, with an effective rate of 96.0%. The survey indicated that the levels of the knowledge of birth defect prevention were 6.6%-96.7%. The male awareness rates were 4.9%-96.3% and the female awareness rates were 7.3%-96.9%. The levels of knowledge of birth defect prevention varied in different education level, per capita annual income of the family and careers. The awareness rates of the some items were increased with the education level (P < 0.05). The awareness rates of some items of cadres, teachers and doctors were higher than that of labors, farmers, businessmen and the other careers (P < 0.05). The awareness rates of some items were increased with per capita annual income of the family (P < 0.05). The responds understood the knowledge mainly through newspapers, radio and television and publicity materials and 90.2% of them wanted to get knowledge of birth defect prevention. Conclusion It is important to increase the publicity of birth defects prevention knowledge and provide the education varying from person to person, and a convenient and effective way of knowledge acquisition to improve the levels of the knowledge of birth defect prevention.