奥沙利铂联合替吉奥治疗晚期结直肠癌的临床效果

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摘要目的探讨奥沙利铂联合替吉奥治疗晚期结直肠癌患者的临床效果。方法回顾性分析2013年3月～2015年1月辽宁省肿瘤医院收治的晚期结直肠癌患者86例的临床资料，根据化疗方案的不同将其分为观察组（46例）和对照组（40例）。观察组采用奥沙利铂联合替吉奥治疗，对照组采用奥沙利铂联合卡培他滨治疗，21 d为1个周期。两组患者均治疗6个周期。比较两组患者临床有效率、疾病控制率、远期预后、不良反应发生率，以及治疗前后肿瘤标志物水平。结果观察组临床有效率（58.70%）和疾病控制率（71.74%）均高于对照组（35.00%、50.00%），差异有统计学意义（P ＜ 0.05）；Log-rank检验显示，观察组死亡风险率显著低于对照组（χ2=3.952，P ＜ 0.05）；观察组（3级以上）总不良反应发生率（10.87%）显著低于对照组（27.50%），差异有统计学意义（P ＜ 0.05）；治疗后，两组患者癌胚抗原（CEA）、甲胎蛋白（AFP）、癌抗原19-9（CA19-9）和胸苷激酶1（TK1）等肿瘤标志物水平显著低于治疗前，且观察组明显低于对照组，差异有统计学意义（P ＜ 0.05）。结论奥沙利铂联合替吉奥方案治疗晚期结直肠癌的效果和安全性较好，且能够有效降低肿瘤标志物水平，改善患者的生存预期。

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	马天飞唐域

关键词 ：奥沙利铂, 替吉奥, 结直肠癌, 预后, 肿瘤标志物

Abstract：Objective To investigate the effects of Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium in the treatment of patients with advanced colorectal cancer. Methods The clinical data of 86 patients with advanced colorectal cancer admitted to Liaoning Cancer Hospital & Institute from March 2013 to January 2015 was analyzed retrospectively, and they were divided into observation group (46 cases) and control group (40 cases) according to the difference of chemotherapy regimen. The observation group was given Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium. The control group was given Oxaliplatin combined with Capecitabine, 21 d was as a course, both groups were treated for 6 courses. The clinical effective rate, disease control rate, long-term prognosis, the incidence of adverse reactions and the levels of tumor markers before and after treatment between the two groups were compared. Results The clinical effective rate (58.70%) and disease control rate (71.74%) in the observation group were significantly higher than those in the control group (35.00%, 50.00%) (P ＜ 0.05); Log-rank test showed that the risk of death in the observation group was significantly lower than that in the control group (χ2 = 3.952, P ＜ 0.05). The total incidence of adverse reactions (above 3 levels) in the observation group (10.87%) was significantly lower than that of the control group (27.50%) (P ＜ 0.05). After treatment, the levels of tumor markers such as carcino-embryonic antigen (CEA), alpha fetoprotein (AFP), cancer antigen 19-9 (CA19-9) and thymidine kinase 1 (TK-1) in the two groups were significantly lower than those before treatment, which of the observation group were significantly lower than those of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion The efficacy and safety of Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium in the treatment of advanced colorectal cancer are good, which can effectively decrease the levels of tumor markers and improve the prognosis of patients.

Key words： Oxaliplatin Tegafur, Gimeracil and Oteracil Potassium Colorectal cancer Prognosis Tumor marker

引用本文:

马天飞唐域. 奥沙利铂联合替吉奥治疗晚期结直肠癌的临床效果[J]. 中国医药导报, 2018, 15(17): 94-97.
MA Tianfei TANG Yu. Clinical efficacy of Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium in the treatment of advanced colorectal cancer. 中国医药导报, 2018, 15(17): 94-97.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I17/94

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