Abstract：Objective To explore the clinical efficacy of Yinzhihuang Granules and microecologics agents on pathological jaundice of newborn. Methods Seventy-five neonates with pathological jaundice treated in Department of Pediatrics, the People's Hospital of Dachang Hui Autonomous County in Langfang City from October 2015 to June 2017 were selected. They were divided into control group (37 cases) and observation group (38 cases) according to random number table. Both groups were given conventional treatment and oral Yinzhihuang Granules, the observation group was given oral microecologics of Bacillus Cereus Tablets besides the conventional treatment for 1 week. The indices were compared before and after treatment in the two groups, including clinical efficacy, serum bilirubin concentration, serum related indicators, jaundice fade time and adverse events. Results After treatment, the total effective rate in the observation group (100.00%) was significantly higher than that in the control group (91.89%) (P ＜ 0.05); after treatment, the serum bilirubin in the observation group was significantly lower than that before treatment and more lower than the control group. Compared with control group, daily decrease of bilirubin was more remarkable and the jaundice fade time was shorter in the observation group, the difference was statistically significant (P ＜ 0.05). After treatment, the hematological parameters such as alanine aminotransferase, total bile acid and total bilirubin in the observation group turned better than those before treatment, which were better than those in the control group (P ＜ 0.05). No serious adverse reactions occurred during treatment. Only one case of mild diarrhea occurred in the observation group and recovered after symptomatic treatment that did not affect the treatment. Conclusion The combination of microecologics of bacillus cereus with Yinzhihuang Granules in the treatment of pathological jaundice of newborn can significantly improve the therapeutic effect, shorten the courses of pathological jaundice of newborn, optimize the serum jaundice related indicators, and does not increase the adverse reactions in children, with good treatment safety, it is worthy of promotion and application in clinic.
李妍. 茵栀黄颗粒与微生态制剂联合治疗新生儿病理性黄疸的效果[J]. 中国医药导报, 2018, 15(17): 76-79.
LI Yan. Effects of Yinzhihuang Granules and microecologics agents on pathological jaundice of newborn. 中国医药导报, 2018, 15(17): 76-79.
[1] 鲍福全，鲍朝霞，张俊荣.蜡样芽胞杆菌片佐治新生儿病理性黄疸临床观察[J].临床合理用药杂志，2012，5（8）：55.
[2] 李举，郝晓广.蓝光联合茵栀黄颗粒治疗新生儿病理性黄疸临床疗效分析[J].中国生化药物杂志，2014，34（1）：121-122.
[3] 伍庭林，伍廷平.新生儿病理性黄疸蓝光、茵栀黄颗粒联合治疗疗效分析[J].中国医药导刊，2013，15（12）：2042， 2044.
[4] 程德勇，丁晓玲，陈浩，等.茵栀黄颗粒治疗新生儿黄疸的临床效果观察[J].中国生化药物杂志，2017，37（6）：99-101.
[5] 林艾.茵栀黄颗粒、蓝光照射联合双岐三联活菌胶囊治疗新生儿黄疸的机制研究[J].海南医学院学报，2017，23（3）：397-400.
[6] 李邹金，冷秋文，唐清萍，等.妈咪爱散联合茵栀黄颗粒、思密达散干预新生儿黄疸的临床疗效观察[J].中国妇幼保健，2012，27（8）：1239-1240.
[7] 钟晓波.茵栀黄颗粒联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸临床分析[J].中药材，2015，38（3）：643-644.
[8] Zaja O，Tiljak MK，Štefanovic M，et al. Correlation of UGT1A1 TATA-box polymorphism and jaundice in breastfed newborns-early presentation of Gilbert's syndrome [J]. J Matern Fetal Neonatal Med，2014，27（8）：844-850.
[9] Christensen RD，Yaish HM，Lemons RS，et al. Neonatal hemolytic jaundice：Morphologic features of erythrocytes that will help you diagnose the underlying condition [J]. Neonatology，2014，105（4）：243-249.
[10] Wang S，Wang X，Li L，et al. Association of preoperative obstructive jaundice with postoperative infectious complications following pancreaticoduodenectomy [J]. Hepatogastroenterology，2013，60（126）：1274-1279.
[11] Sharma J，Gairola S，Gaur RD，et al. The treatment of jaundice with medicinal plants in indigenous communities of the Sub-Himalayan region of Uttarakhand，India [J]. J Ethnopharmacol，2012，143（1）：262-291.
[12] Christensen RD，Nussenzveig RH，Reading NS，et al. Variations in Both alpha-Spectrin（SPTA1）and beta-Spectrin（SPTB）in a Neonate with Prolonged Jaundice in a Family where Nine Individuals Had Hereditary Elliptocytosis [J]. Neonatology，2014，105（1）：1-4.
[13] Pei S，Yuan W，Mai H，et al. Efficacy of dynamic indices in predicting fluid responsiveness in patients with obstructive jaundice [J]. Physiol Meas，2014，35（3）：369-382.
[14] Chu YL，Wang XF，Gao XZ，et al. Endoscopic ultrasonography in tandem with endoscopic retrograde cholangiopancreatography in the management of suspected distal obstructive jaundice [J]. Eur J Gastroenterol Hepatol，2013，25（4）：455-459.
[15] 李婕，胡燕.蓝光联合茵栀黄颗粒治疗新生儿病理性黄疸的临床研究[J].中国临床药理学杂志，2015，31（18）：1809-1811.
[16] 徐睿霞，王甫琴，吴亚臻，等.茵栀黄口服液联合清蛋白治疗新生儿病理性黄疸疗效及安全性研究[J].重庆医学，2017，46（4）：530-532.
[17] 路军.茵栀黄口服液联合蓝光照射治疗新生儿病理性黄疸的临床疗效研究[J].中医药学报，2014，42（5）：132-134.
[18] 李妍.茵栀黄颗粒治疗新生儿病理性黄疸的临床效果分析[J].世界中医药，2017，12（6）：1340-1342，1346.
[19] 王智惠，王成秀，李芳.布拉氏酵母菌散联合蓝光治疗新生儿病理性黄疸临床疗效观察[J].西部医学，2014， 26（5）：651-652，655.
[20] 赵玉凤.蓝光照射联合茵栀黄口服液治疗新生儿病理性黄疸的临床体会[J].中国医师进修杂志，2015，38（s1）：169-170.
2018, Vol. 15 
京公网安备 11010502046598号