The effect of hydrodissection with diluted pituitrin on ovarian function after laparoscopic operation on unilateral ovarian endometriosis cyst
PAN Zhuo1 HU Chang′e2 SU Jingjing3
1.Department of Obstetrics and Gynecology, the Second Hospital Affiliated to Dalian Medical University, Liaoning Province, Dalian 116021, China;
2.Department of Obstetrics and Gynecology, Maternal and Child Care Service Center of Xiangtan City, Hu′nan Province, Xiangtan 411104, China;
3.Department of Obstetrics and Gynecology, Panjin People′s Hospital, Liaoning Province, Panjin 124221, China
Abstract：Objective To explore the effect of hydrodissection with diluted pituitrin on ovarian function after laparoscopic operation on unilateral ovarian endometriosis cyst. Methods Sixty patients with unilateral ovarian endometriosis cyst underwent laparoscopic cystectomy in Panjin People′s Hospital from March 2015 to January 2017 were selected. According to operation methods, they were divided into three groups: pituitrin group (group A), physiological saline group (group B) and electro surgical instruments group (group C), with 20 cases in each group. The operation time, hemoglobin and anti-müllerian hormone (AMH) values before and after operation were compared. Results There were no significant differences among the three groups in operation time, hemoglobin value before and after operation (P ＞ 0.05). After operation for 1, 3, 6 months, the levels of serum AMH in the three groups were all lower than those before operation, the differences were statistically significant (P ＜ 0.05). After operation for 1, 3, 6 months, there were no significant differences in the serum AMH value between group A and group B (P ＞ 0.05), but the indices of both groups were higher than that of group C (P ＜ 0.05). Conclusion The ovarian reserve function will be reduced after laparoscopic cystectomy for unilateral ovarian endometriosis cyst, and the reserve function can be protected by hydrodissection with diluted pituitrin.
潘卓1 胡嫦娥2 苏晶晶3. 腹腔镜下垂体后叶素水囊剥除单侧卵巢子宫内膜异位囊肿对卵巢功能的影响[J]. 中国医药导报, 2018, 15(17): 72-75.
PAN Zhuo1 HU Chang′e2 SU Jingjing3. The effect of hydrodissection with diluted pituitrin on ovarian function after laparoscopic operation on unilateral ovarian endometriosis cyst. 中国医药导报, 2018, 15(17): 72-75.
[1] Suchy T，Stepan J. Extragenital endometriosis as a subject of interest for the surgeon [J]. Rozhl Chir，2004，83（5）：239-241.
[2] Derouich S，Attia L，Slimani O，et al. Medical treatment of endometriosis [J]. Tunis Med，2015，93（7）：407-412.
[3] Yamamoto A，Johnstone EB，Bloom MS，et al. A higher prevalence of endometriosis among Asian women does not contribute to poorer IVF outcomes [J]. J Assist Reprod Genet，2017，34（6）：765-774.
[4] Missmer SA，Hankinson SE，Spiegelman D，et al. Reproductive history and endometriosis among premenopausal women [J]. Obstet Gynecol，2004，104（5 Pt 1）：965-974.
[5] Soliman AM，Coyne KS，Zaiser E，et al. The burden of endometriosis symptoms on health-related quality of life in women in the United States： a cross-sectional study [J]. J Bychosom Obstet Gynaecol，2017，38（4）：238-248.
[6] Working group of ESGE，ESHRE，and WES，Saridogan E，Becker CM，et al. Recommendations for the surgical treatment of endometriosis-part1：ovarian Endometrioma [J]. Gynecol Surg，2017，14（1）：27.
[7] Singh SS，Suen MW. Surgery for endometriosis：beyond medical therapies [J]. Fertil Steril，2017，107（3）：549-554.
[8] Qi X，Pang Y，Qiao J. The role of anti-Mullerian hormone in the pathogenesis and pathophysiological characteristics of polycystic ovary syndrome [J]. Eur J Obstet Gynecol Reprod Biol，2016，199：82-87.
[9] Nouri M，Aghadavod E，Khani S，et al. Association between BMI and gene expression of anti-Müllerian hormone and androgen receptor in human granulosa cells in women with and without polycystic ovary syndrome [J]. Clin Endocrinol，2016，85（4）：590-595.
[10] Guzick DS，Silliman NP，Adamson GD，et al. Prediction of pregnancy in infertile women based on the American Society for Reproductive Medicine's revised classification of endometriosis [J]. Fertil Steril，1997，67（5）：822-829.
[11] Busacca M，Vignali M. Ovarian endometriosis：from pathogenesis to surgical treatment [J]. Curr Opin Obstet Gynecol，2003，15（4）：321-326.
[12] Bischoff F，SimBon JL. Genetics of endometriosis：heritability and candidate genes [J]. Best Pract Res Clin Obstet Gynaecol，2004，18（2）：219-232.
[13] Yamaguchi K，Mandai M，Toyokuni S，et al. Contents of endometriotic cysts，especially the high concentration of free iron，are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress [J]. Clin Cancer Res，2008，14（1）：32-40.
[14] Wu WS. The signaling mechanism of ROS in tumor progression [J]. Cancer Metastasis Rev，2006，25（4）：695-705.
[15] Defrère S，González-Ramos R，Lousse JC，et al. Insights into iron and nuclear factor-kappa B（NF-kappa B） involvement in chronic inflammatory processes in peritoneal endometriosis [J]. Histol Histopathol，2011，26（8）：1083-1092.
[16] Sanchez AM，VCanò P，SomCliana E，et al. The distinguishing cellular and molecular features of the endometriotic ovarian cyst：from pathophysiology to the potential endometrioma-mediated damage to the ovary [J]. Hum Reprod Update，2014，20（2）：217-230.
[17] Matsuzaki S，Schubert B. Oxidative stress status in normal ovarian cortex surrounding ovarian endometriosis [J]. Fertil Steril，2010，93（7）：2431-2432.
[18] Asgari Z，Rouholamin S，Hosseini R，et al. Comparing ovarian reserve after laparoscopic excision of endometriotic cysts and hemostasis achieved either by bipolar coagulation or suturing：a randomized clinical trial [J]. Arch Gynecol Obstet，2016，293（5）：1015-1022.
[19] Guibourdenche J，Lucidarme N，Chevenne D，et al. Anti-Müllerian hormone levels in serum from human foetuses and children：pattern and clinical interest [J]. Mol Cell Endocrinol，2003，211（1/2）：55-63.
[20] 郭亮生，胡敏，郑丽君，等.腹腔镜下垂体后叶素注射对卵巢储备功能的影响[J].实用妇产科杂志，2014，30（7）：548-551.
[21] Qiong-Zhen R，Ge Y，Deng Y，et al. Effect of vasopressin injection technique in laparoscopic excision of bilateral ovarian endometriomas on ovarian reserve：prospective randomized study [J]. J Minim Invasive Gynecol，2014， 21（2）：266-271.
2018, Vol. 15 
京公网安备 11010502046598号