Abstract：[Abstract] Solid oral drugs must undergo dissolution in gastrointestinal fluid before they can be absorbed and reach the systemic circulation. Dissolution test is an in vitro method that simulates the disintegration and dissolution of solid oral drugs in the gastrointestinal tract, which plays a more and more important role in the prescription optimization and quality evaluation. A lot of studies on dissolution technology have been made to obtain higher levels of in vivo and in vitro correlation and ensure the consistency of the quality and efficacy of oral dosages. This paper summarized the research progress of dissolution medium and dissolution device and their applications in some particular dosages, it is hoped to provide some reference for other researchers committed to quality evaluation of oral solid preparation and development of generic drugs.
张 伟1 刘建芳2 赵彩霞2. 口服固体制剂溶出度测定方法的研究与应用进展[J]. 中国医药导报, 2016, 13(3): 48-50，63.
ZHANG Wei1 LIU Jianfang2 ZHAO Caixia2. Advances in the research and application of dissolution method for oral solid dosage forms. 中国医药导报, 2016, 13(3): 48-50，63.
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