Abstract:Objective To systematically evaluate the clinical effectiveness and safety of Flurbiprofen axetil preemptive analgesia combined Propofol anesthesia on painless abortion. Methods The databases of PubMed, CNKI, Wanfang and VIP were retrieved from the inception to Mar 2017. The literature search was conducted using the following terms: "flurbiprofen "OR" flurbiprofen axetil" AND "preemptive analgesia" AND "induced abortion" OR "abortion technique" OR "abortion". Meta analysis was conducted by Stata 12.0 software after the data was extracted. The pooled results expressed as odds ratio and weighted mean difference, with 95% confidence interval, respectively. The fixed-effect or random-effect model was performed according to the heterogeneity. Results 14 literatures and involved in 1261 patients were analyzed. Meta analysis showed that the patients with Flurbiprofen axetil preemptive analgesia was significantly associated with shorter induction time (WMD=-1.87, P=0.02), lower intraoperative MAP (P=0.04), postoperative MAP (P=0.00), intraoperative HR (P=0.00) and postoperative HR (P=0.03).And treatment with Flurbiprofen axetil preemptive analgesia also decreased the Propofol induced pain (OR=0.56, P=0.04), intraoperative patient writhe (OR=0.23, P=0.00), respiratory depression (OR=0.10, P=0.00) and Propofol dos (WMD=-31.16, P=0.00). The shorter awakening time (WMD=-1.54, P=0.00) and the lesser incidence of postoperation nausea (OR=0.56, P=0.04), uterus contraction pain (OR=0.15, P=0.00) and postoperation visual analogue scale (WMD=-2.18, P=0.00) was found in patients with Flurbiprofen axetil preemptive analgesia than the patients in control group. Conclusion This meta analysis suggests that Flurbiprofen axetil preemptive analgesia combined Propofol anesthesia on painless abortion is a safe and effective approach based on current evidence. But further randomized controlled trials should be undertaken to confirm these findings.
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▲通讯作者
作者简介: 张恒(1982-),男,湖北宜昌人,硕士,主管药师,主要从事医院药学工作。
引用本文:
张恒 饶坤林▲ 黄隽敏. 氟比洛酚酯复合丙泊酚麻醉用于无痛人流术超前镇痛临床效果的Meta分析[J]. 中国医药导报, 2017, 14(30): 115-120.
ZHANG Heng RAO Kun-lin▲ HUANG Junmin. The meta analysis of the clinical effects of Flurbiprofen axetil preemptive analgesia combined Propofol anesthesia on painless abortion. 中国医药导报, 2017, 14(30): 115-120.