Risk factors of stable coronary heart disease and relationship with neutrophil/lymphocyte ratio
JIANG Yun1 WU Li1▲ ZHAO Long2
1.Ward Two Department of General Medicine, Tumor Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China; 2.Department of Cardiology, Yili Youyi Hospital, Xinjiang Uygur Autonomous Region, Yili 835000, China
Abstract：Objective To study the risk factors of stable coronary heart disease and relationship between neutrophil-to-lymphocyte ratio (NLR) and it. Methods From January to December 2016, in Yili Youyi Hospital, 600 patients with chest pain and suspected as coronary heart disease were retrospectively analyzed. According to the results of coronary angiography, patients were divided into coronary heart disease (CAD) group (n = 300) and control group (n = 300). Disease risk factors of general data in two groups were compared by single factor analysis, disease risk factors were screened by two classification Logistic regression analysis, the Gensini scores of patients with different NLR levels were compared, the value of NLR in the diagnosis of disease was analyzed by drawing ROC curve. Results The smoking history, hypertension history, diabetes history, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), hemoglobin, WBC and NLR in CAD group and control group were compared, the differences were statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that smoking (OR = 2.331, 95% CI: 1.590-4.505, P < 0.05), LDL-C (OR = 1.737, 95% CI: 1.327-2.274, P < 0.05), NLR (OR = 1.552, 95% CI: 1.230-3.329, P < 0.05) were independent risk factor for CHD patients, and HDL-C (OR = 0.456, 95% CI: 0.261-0.798, P < 0.05) was the independent protective factors for CAD patients. Gensini scores stratified in different NLR of CAD group were compared, the difference was statistically significant (P < 0.05), Gensini scores was significantly higher in patients with higher NLR (P < 0.05). ROC curve showed that the area under the curve was 0.834 (95% CI: 0.802-0.867), and when the NLR value was 2.5, the diagnosis efficiency was highest, the sensitivity was 77.0%, and the specificity was 80.7%. Conclusion NLR may be a good predictor of stable coronary heart disease.
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2018, Vol. 15 
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