Abstract：Objective To investigate effect of Atorvastatin combined with Dimethylbiguanide in treating elderly type 2 diabetes with dyslipidemia. Methods The clinical data of 280 cases of elderly patients diagnosed as type 2 diabetes with dyslipidemia in Chengyang People's Hospital from January 2014 to January 2017 was analyzed, they were divided into two control group (Atorvastatin) and observation group (Atorvastatin combined with Dimethylbiguanide), with 140 cases in each group. The levels of fasting blood glucose (FBG), postprandial blood glucose (PBG), glycosylated hemoglobin (HbA1c), fasting insulin (Fins), insulin resistance (HOMA-IR), triacylglycerol (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterin (LDL-C) of two groups were detected before and after treatment. The clinical effects of the two groups were observed. Results The levels of FBG, PBG, HbA1c, Fins, HOMA-IR, TG, TC, HDL-C, LDL-C between two groups had no significant differences before treatment (P ＞ 0.05). After treatment, the levels of FBG, PBG, HbA1c, Fins, HOMA-IR, TG, TC, LDL-C in the two groups were all significantly lower than those before treatment, while the levels of HDL-C were higher than those before treatment (P ＜ 0.05). After treatment, the levels of FBG, PBG, HbA1c, Fins, HOMA-IR, TG, TC, LDL-C of observation group were lower than those of control group, while the level of HDL-C was higher than that of control group (P ＜ 0.05). The total effective rate of observation group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). Conclusion Atorvastatin combined with Dimethylbiguanide in treating elderly type 2 diabetes with dyslipidemia can significantly improve the levels of blood glucose and blood lipid, the clinical efficacy is remarkable and it is worthy of promotion and application.
王永海1 江梅菊1▲ 王琳2 周红利1. 阿托伐他汀联合二甲双胍治疗老年2型糖尿病伴血脂异常的效果[J]. 中国医药导报, 2018, 15(13): 113-116,155.
WANG Yonghai1 JIANG Meiju1▲ WANG lin2 ZHOU Hongli1. Efficacy of Atorvastatin combined with Dimethylbiguanide in treating elderly type 2 diabetes with dyslipidemia. 中国医药导报, 2018, 15(13): 113-116,155.
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2018, Vol. 15 
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