Abstract：Objective To investigate the effect of different concentrations of the incidence and onset time of rate of Fentanyl-induced cough. Methods From January to November 2017, 300 patients with general anesthesia for elective surgery in Affiliated Hospital of Yangzhou University were selected as research subjects. They were randomly divided into six groups using a random number table, non dilution control group A (group A1). One times dilute group A (group A2)︰ Fentanyl and normal saline 1︰1 were diluted and was uniform; 2 times dilute group A (group A3)︰ Fentanyl and normal saline 1︰2 were diluted and was uniform, and those three groups were injected at 5 s, non dilution control group B (group B1). One times dilute group B (group B2)︰ Fentanyl and normal saline 1︰1 were diluted and was uniform; 2 times dilute group B (group B3)︰ Fentanyl and normal saline 1︰2 were diluted and was uniform, and those three groups were injected at 10 s, with 50 cases in each group. The time of cough and the incidence rate of cough among the six groups were recorded and compared. Results When the concentration of the drug was the same and the speed of drug delivery was different, the cough onset time in group B1 were significantly longer than group A1 (P < 0.05). The incidence of cough in group B1 were significantly lower than group A1 (P < 0.05), the cough onset time in group B2 were significantly longer than group A2 (P < 0.05). The incidence of cough in group B2 were significantly lower than group A2 (P < 0.05), the cough onset time in group B3 were significantly longer than group A3 (P < 0.05). When the speed of drug delivery was the same and the concentration of the drug was different, compared with group group A1, there was no statistically significant differences of cough onset time in group A2 and group A3 (P > 0.05), the incidence of cough in group A2 were lower than group A1 (P ＜ 0.05), and the incidence of cough in group A3 were significantly lower than group A1 and group A2 (P < 0.05). Compared with group group B1, there was no longer of the cough onset time in group B2 (P > 0.05), and the incidence of cough in group B2 were lower than group B1, the differen (P < 0.05ce was statistically signifincant). Compared with group B1 and group B2, the cough onset time in group B3 were significantly longer than group B1 and group B2, and the incidence of cough in group B3 were significantly lower than group B1 and group B2, the differences were statistically significant (P < 0.05). Conclusion Reducing the speed of drug delivery and concentration of Fentanyl, which can prolonging the time of the cough onset time, reduce the incidence of cough, when the Fentanyl and normal saline 1︰2 were diluted and was uniform, which can significant inhibition of cough, thus it is significance to improve the safety of the patients′ anesthesia.
王茂华 张静 赵梦雅 陈茂桂 张转 孙晓红 孙建宏. 不同浓度芬太尼对诱发呛咳时间与发生率的影响[J]. 中国医药导报, 2018, 15(13): 85-88.
WANG Maohua ZHANG Jing ZHAO Mengya CHEN Maogui ZHANG Zhuan SUN Xiaohong SUN Jianhong. Effect of different concentrations of the incidence and onset time of rate of Fentanyl-induced cough. 中国医药导报, 2018, 15(13): 85-88.
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2018, Vol. 15 
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